Engineering antibodies with cancer‐associated binding sites
BMEMat, EarlyView.This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian +4 more
wiley +1 more source
Effect of turbulence and viruses on prokaryotic cell size, production and diversity [PDF]
, 2009 Andrea Malits, Markus G. Weinbauer
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In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins
ChemBioChem, Accepted Article.Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska +2 more
wiley +1 more source
Direct Measurement of the Relative Contributions of Turgor Pressure, the Peptidoglycan Cell Wall and Cytoskeletal Filaments to Gram-negative Prokaryotic Cell Mechanics using AFM [PDF]
, 2009 Mingzhai Sun +4 more
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Characterization of DnaB‐DnaG Interaction in M. tuberculosis using a SAXS‐Based Dissociation Assay
ChemBioChem, Accepted Article.We studied the complex interactions between helicase and primase, two key components of the replisome involved in DNA replication in Mycobacterium tuberculosis. Utilizing purified, complementary domains of these proteins, we employed a surface plasmon resonance (SPR) analysis and a cross‐linking assay to characterize their binding dynamics.
Barak Akabayov, Adi Dayan, Stefan Ilic
wiley +1 more source
One-way ticket to the cell pole: Plasmid transport by the prokaryotic tubulin homolog TubZ [PDF]
, 2010 Daniela Barillà
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ChemCatChem, EarlyView.An enzyme that has been identified and characterized as capable of hydrolyzing paclitaxel (Taxol), a key anticancer drug derived from Pacific yew (Taxus brevifolia) has been identified. Molecular docking (MD) simulations map the catalytic triad and critical residues that drive substrate‐enzyme interactions. The findings indicate the catalytic potential
Jinfen Su +3 more
wiley +1 more source
From Water and Ions to Crowded Biomacromolecules:In VivoStructuring of a Prokaryotic Cell [PDF]
, 2011 Jan J. Spitzer
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Parallelized disruption of prokaryotic and eukaryotic cells via miniaturized and automated bead mill [PDF]
, 2020 Roman Jansen +6 more
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Electroenzymatic CO2 Reduction Using Formate Dehydrogenase: Direct and Mediated Catalysis
ChemElectroChem, EarlyView.Formate dehydrogenase from Desulfovibrio desulfuricans (DdFDH) demonstrates the ability to reversibly catalyze the electrochemical reduction of CO2 into formate, offering a potential pathway for CO2 mitigation and production of value‐added compounds.
Navendu Paul +4 more
wiley +1 more source