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Prolactinoma

Prolactinomas are benign pituitary tumors characterized by excessive secretion of prolactin. While more common in females, these tumors can also significantly impact male patients, leading to symptoms such as hypogonadism, infertility and gynecomastia.
Yatavelli RKR, Kaur J, Bhusal K.
europepmc   +2 more sources

The clinical and therapeutic profiles of prolactinomas associated with germline pathogenic variants in the aryl hydrocarbon receptor interacting protein (AIP) gene

Frontiers in Endocrinology, 2023
IntroductionProlactinomas are the most frequent type of pituitary adenoma encountered in clinical practice. Dopamine agonists (DA) like cabergoline typically provide sign/ symptom control, normalize prolactin levels and decrease tumor size in most ...
Laurent Vroonen, Albert Beckers, Severine Camby, Thomas Cuny, Pablo Beckers, Marie-Lise Jaffrain-Rea, Marie-Lise Jaffrain-Rea, Muriel Cogne, Luciana Naves, Amandine Ferriere, Pauline Romanet, Atanaska Elenkova, Auli Karhu, Auli Karhu, Thierry Brue, Thierry Brue, Anne Barlier, Patrick Pétrossians, Adrian F. Daly   +18 more
doaj   +1 more source

Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas

Frontiers in Neurology, 2021
Prolactinomas have been reported for the failure of cognitive functions. However, the electrophysiological mechanisms of attention processing in prolactinomas remain unclear. In a visual mission, we monitored the scalp electroencephalography (EEG) of the
Chenglong Cao, Chenglong Cao, Yu Wang, Jia Liu, Aobo Chen, Jinjiang Lu, Guozheng Xu, Guozheng Xu, Jian Song, Jian Song   +9 more
doaj   +1 more source

Treatment of Prolactinoma

Medicina, 2022
Prolactinomas are the commonest form of pituitary neuroendocrine tumor (PitNET), representing approximately half of such tumors. Dopamine agonists (DAs) have traditionally been the primary treatment for the majority of prolactinomas, with surgery ...
Warrick J. Inder, Christina Jang
doaj   +1 more source

The efficacy and safety of quinagolide in hyperprolactinemia treatment: A systematic review and meta-analysis

Frontiers in Endocrinology, 2023
PurposeThree dopamine agonists [bromocriptine, cabergoline, and quinagolide (CV)] have been used for hyperprolactinemia treatment for decades. Several studies have reviewed the efficacy and safety of bromocriptine and cabergoline.
Yanyang Zeng, Qingliang Huang, Yunzhi Zou, Jiacong Tan, Wu Zhou, Meihua Li   +5 more
doaj   +1 more source

Prolactinoma [PDF]

Arquivos Brasileiros de Endocrinologia & Metabologia, 2014
Os prolactinomas são os adenomas de hipófise mais comuns e frequentemente afetam mulheres jovens, em faixa etária de fertilidade. A hiperprolactinemia causa hipogonadismo, irregularidade menstrual ou amenorreia em mulheres, níveis baixos de testosterona sérica em homens e infertilidade e disfunção sexual em ambos os gêneros.
Glezer, Andrea, Bronstein, Marcello D.
openaire   +4 more sources

Operative treatment of cystic prolactinomas: a retrospective study

BMC Endocrine Disorders, 2023
Background The optimal therapeutic approach for cystic prolactinomas remains unclear. This study aimed to evaluate the remission rates of prolactinoma patients after surgical treatment and the risk factors affecting postoperative remission in cystic ...
Weijie Su, Kejun He, Yibing Yang, Jiakun Xu, Xixi Li, Hongxing Tang, Jia Yang, Lixuan Yang   +7 more
doaj   +1 more source

The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas

BMC Endocrine Disorders, 2021
Background Prolactinoma is a functional pituitary adenoma that secretes excessive prolactin. Dopamine agonists (DAs) such as bromocriptine (BRC) are the first-line treatment for prolactinomas, but the resistance rate is increasing year by year, creating ...
Shuman Wang, Aihua Wang, Yu Zhang, Kejing Zhu, Xiong Wang, Yonggang Chen, Jinhu Wu   +6 more
doaj   +1 more source

Is prolactin receptor signaling a target in dopamine-resistant prolactinomas?

Frontiers in Endocrinology, 2023
The hypothalamic neuroendocrine catecholamine dopamine regulates the lactotroph function, including prolactin (PRL) secretion, proliferation, and apoptosis. The treatment of PRL-secreting tumors, formerly known as prolactinomas, has relied mainly on this
Jimena Ferraris
doaj   +1 more source

Neuropsychological Alterations of Prolactinomas’ Cognitive Flexibility in Task Switching

Brain Sciences, 2023
Prolactinomas have been reported to impair cognition in broad aspects. However, few studies investigated the influence of prolactinomas on cognitive flexibility never mentioning the underlying neural and electrophysiological mechanism.
Chenglong Cao, Wen Wen, Aobo Chen, Shuochen Wang, Guozheng Xu, Chaoshi Niu, Jian Song   +6 more
doaj   +1 more source