Results 51 to 60 of about 7,269 (215)

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Improving quality of life in patients with pituitary tumours [PDF]

, 2017
Evaluation of health-related quality of life (QoL) in people with pituitary tumours has received much attention over the last 10-15 years. Most of them show impaired QoL, but little is known about how to prevent impairment or how to improve QoL.
Crespo, Iris, Martínez Momblán, Ma. Antonia, Resmini, Eugenia, Santos Vives, Alicia, Valassi, Elena, Webb, S. M. (Susan M.), 1952-   +5 more
core   +1 more source

The Mechanism and Pathways of Dopamine and Dopamine Agonists in Prolactinomas

Frontiers in Endocrinology, 2019
Dopamine agonists such as bromocriptine and cabergoline are the predominant treatment drugs for prolactinoma by inhibiting prolactin secretion and shrinking tumor size.
Xiaoshuang Liu, Chao Tang, Guodao Wen, Chunyu Zhong, Jin Yang, Junhao Zhu, Chiyuan Ma   +6 more
doaj   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Very Long‐Term Follow‐Up of Multidimensional Health‐Related Quality of Life After Endoscopic Endonasal Surgery for Pituitary Adenomas: A Prospective Cohort Study

Head &Neck, Volume 48, Issue 4, Page 1088-1096, April 2026.
ABSTRACT Background To evaluate postoperative health‐related quality of life (HRQoL) for pituitary adenoma patients, multidimensional assessment is important. Available data is limited on long‐term follow‐up. Methods Prospectively, 52 nonfunctioning (NFA) and functioning (FA) pituitary adenoma patients were included.
Gonneke E. Joustra, Nathalie F. van Rhee, Marc C. den Heijer, Astrid G. W. Korsten‐Meijer, Robert A. Feijen, György B. Halmos, Jos M. A. Kuijlen, Karin M. Vermeulen   +7 more
wiley   +1 more source

Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications. [PDF]

, 2009
peer reviewedaudience: researcher, professionalGermline mutations of the aryl hydrocarbon receptor (AHR)-interacting protein (AIP) gene confer a predisposition to pituitary adenomas (PA), usually in the setting of familial isolated PA. To provide further
Jaffrain-Rea, Marie-Lise, Angelini, M., Gargano, D., Tichomirowa, M. A., Daly, Adrian, Vanbellinghen, Jean-François, D'Innocenzo, E., Barlier, Anne, Giangaspero, F., Esposito, Vincenzina, Ventura, L., Arcella, A., Theodoropoulou, M., Naves, Luciana Ansaneli, Fajardo, C., Zacharieva, S., Rohmer, V., Brue, T., Gulino, A., Cantore, G., Alesse, E., Beckers, Albert   +21 more
core   +1 more source

Prognostic factors for surgical treatment of prolactin-secreting pituitary adenomas

Frontiers in Surgery
IntroductionUsually, prolactinomas are treated with dopamine agonists (DA). Surgery is considered an option when the patient cannot bear or does not respond positively to DA therapy.AimThis study aims to determine the early and late outcomes of surgery ...
Oleksandr Voznyak, Iaroslav Zinkevych, Andrii Lytvynenko, Nazarii Hryniv, Roman Ilyuk, Nazarii Kobyliak, Nazarii Kobyliak   +6 more
doaj   +1 more source

Patients With Pituitary Neuroendocrine Tumours Requiring Neurosurgery –Who Is Referring Them?

Clinical Endocrinology, Volume 104, Issue 4, Page 352-361, April 2026.
ABSTRACT Objective Patients living with pituitary neuroendocrine tumours (PitNETs) present with a spectrum of clinical manifestations and often follow a circuitous route to diagnosis, resulting in diagnostic delays. The objective of this study is to identify and report the various sources of referrals for patients who underwent pituitary resection for ...
Doua S. Ahmed, Brian Herron, Stephen Cooke, Philip Weir, Jane Evanson, Estelle G. Healy, Karen R. Mullan, Stephanie G. Craig, Jacqueline A. James, Márta Korbonits, Steven J. Hunter, Paul Benjamin Loughrey   +11 more
wiley   +1 more source

Clinical Features, Therapeutic Trends, and Outcome of Giant Prolactinomas: A Single-Center Experience Over a 12-Year Period

Clinical Medicine Insights: Endocrinology and Diabetes, 2020
Background: Management of giant prolactinomas presents a different challenge than the management of traditional prolactinomas. Objective: The aim of this study was to report the largest long-term single-center study of giant prolactinomas to analyze ...
Mussa H Almalki, Naji Aljohani, Saad Alzahrani, Ohoud Almohareb, Maswood M Ahmad, Abdullah A Alrashed, Fahad Alshahrani, Badurudeen Mahmood Buhary   +7 more
doaj   +1 more source

Comparison of Ki-67 index values between patients with operated giant prolactinomas and macroprolactinomas

Turkish Journal of Internal Medicine, 2022
Objective: Data on whether there is a histopathological difference in cellular features as determined with Ki-67 between giant prolactinomas and smaller macroprolactinomas are not fully clear.
Soner Cander, Özen Öz Gül
doaj   +1 more source