Results 41 to 50 of about 597,091 (260)

Promising Immune Treatment of Advanced Cutaneous Squamous Cell Carcinoma with Cemiplimab—Real-World Experience in the Global SARS-CoV-2 Pandemic

Current Oncology, 2022
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent non-melanoma skin cancer. The standard curative treatment is surgical resection, but the treatment of locally advanced and metastatic disease apart from radiotherapy is currently based ...
Marta Pabianek, Aleksandra Lesiak, Dariusz Nejc, Łukasz Kuncman, Joanna Narbutt, Małgorzata Skibińska, Magdalena Ciążyńska   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Relation between 25-hydroxy vitamin D and diabetic retinopathy in Egyptian patients with type 2 diabetes mellitus

Journal of the Arab Society for Medical Research
Background/aim Diabetic retinopathy (DR) is one of the leading causes of blindness in people whose ages range from 20 to 64 worldwide. This study aims to evaluate the association of serum 25-hydroxy (OH) vitamin D deficiency and DR in type 2 diabetes ...
Mervat E. Elwakeel, Fatma M. El-Senosy, Nesma S. Mohammed, Heba M. Abdelrahman, Eman E. Ebrihem   +4 more
doaj   +1 more source

Pathophysiology of proliferative vitreoretinopathy in retinal detachment

, 2013
Because proliferative vitreoretinopathy cannot be effectively treated, its prevention is indispensable for the success of surgery for retinal detachment. The elaboration of preventive and therapeutic strategies depends upon the identification of patients
Garweg, Justus G., Halberstadt, Markus, Tappeiner, Christoph   +2 more
core   +1 more source

The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas [PDF]

, 2010
Background: New drugs are constantly sought after to improve the survival of patients with malignant gliomas. The ideal substance would selectively target tumor cells without eliciting toxic side effects.
Senft, Christian, Priester, Maike, Kögel, Donat, Seifert Volker, Weissenberger Jakob, Donat Kögel, Senft Christian, Polacin, Margareth, Margareth Polacin, Christian Senft, Maike Priester, Seifert, Volker, Polacin Margareth, Volker Seifert, Jakob Weissenberger, Priester Maike, Kögel Donat, Weissenberger, Jakob   +17 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A mathematical model for fibro-proliferative wound healing disorders [PDF]

, 1996
The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of ...
Olsen, L., Maini, P K, Sherratt, J. A., Philip K. Maini, Maini, P. K., Olsen, L, Sherratt, Jonathan Adam, Maini, Philip, Jonathan A. Sherrati, Maini, PK, Sherratt, JA, Lure Olsen   +11 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Proliferative Necrotising Otitis Externa in a Cat Treated Successfully With Oclacitinib Maleate With Two Delayed Relapses

Veterinary Medicine and Science
This case report documents the successful treatment of a cat with proliferative necrotizing otitis externa (PNOE) using oclacitinib. Novel to this report, two episodes of delayed relapses occurred prior to complete spontaneous resolution, with an ...
Tian Chee, David Robson
doaj   +1 more source

HbA1C, proliferative and non-proliferative retinopathy in diabetic patients

Medicina Clínica Práctica, 2023
Background: Retinopathy is one of the most common microvascular complications caused by diabetes, which occurs due to changes in blood capillaries. One of the most important factors to determine the progression of retinopathy is measuring HbA1C.
Faeze Poshtchaman, Alemeh Dehnabi, Zahra Poshtchaman, Batul Birjandi   +3 more
doaj   +1 more source