Results 81 to 90 of about 10,365 (241)

Upshot of Some Bioactive Compounds on Angiogenesis in Retinal Pigment Epithelial Cells

Journal of Cellular and Molecular Medicine, Volume 29, Issue 1, January 2025.
ABSTRACT Nowadays, the use of monoclonal antibodies to target angiogenic signalling pathways is common, but, unfortunately, the clinical activity of these agents is limited. Thus, the development of approaches targeting multiple pathways for anti‐angiogenic effect will lead to increase the clinical benefit.
Serkan Sen, Murat Kasikci
wiley   +1 more source

Salinomycin inhibits proliferative vitreoretinopathy formation in a mouse model.

PLoS ONE, 2020
Proliferative vitreoretinopathy (PVR) is a progressive disease that develops in a subset of patients who undergo surgery for retinal detachment repair, and results in significant vision loss.
Alison M Heffer, Victor Wang, Richard T Libby, Steven E Feldon, Collynn F Woeller, Ajay E Kuriyan   +5 more
doaj   +1 more source

Human cytokines activate JAK–STAT signaling pathway in porcine ocular tissue [PDF]

, 2015
Background: The JAK/STAT (Janus Tyrosine Kinase, Signal Transducers and Activators of Transcription) pathway is associated with cytokine or growth factor receptors and it is critical for growth control, developmental regulation and homeostasis.
Barteneva, Natasha S, Fasler-Kan, Elizaveta, Flammer, Josef, Huwyler, Jörg, Ketterer, Sylvia, Meyer, Peter, Nurzhanova, Asil, Reschner, Anca, Wunderlich, Kerstin   +8 more
core   +1 more source

Modeling and Recognition of Retinal Blood Vessels Tortuosity in ROP Plus Disease: A Hybrid Segmentation–Classification Scheme

International Journal of Intelligent Systems, Volume 2025, Issue 1, 2025.
Retinopathy of prematurity (ROP) remains a significant cause of childhood blindness despite advancements in neonatal care. Identifying the plus form of ROP, characterized by dilated and tortuous blood vessels, is crucial for timely intervention. This study introduces an intelligent segmentation–classification system for the autonomous detection of ...
Alice Varysova, Jan Kubicek, Marek Penhaker, Martin Augustynek, David Oczka, Kristyna Marsolkova, Juraj Timkovic, Zhiyuan Qi   +7 more
wiley   +1 more source

CHARACTERISTICS OF RETINAL DETACHMENT PATIENTS WITH PROLIFERATIVE VITREORETINOPATHY AT Dr. SOETOMO GENERAL ACADEMIC HOSPITAL

IJRETINA (International Journal of Retina), 2019
Introduction: The aim of this study is to evaluate the incidence and characteristics of retinal detachment patients with proliferative vitreoretinopathy.
Ifan Romadhon Lukmana, Sauli Ari Widjaja, Wimbo Sasono, Muhammad Firmansjah, Ima Yustiarini, Ady Dwi Prakosa, Moestidjab Moestidjab, Gatut Suhendro   +7 more
doaj   +1 more source

Short-Term Total Tamponade with Perfluorocarbon Liquid and Silicone Oil in Complex Rhegmatogenous Retinal Detachment with Severe Proliferative Vitreoretinopathy

Clinical Ophthalmology, 2023
Omar Trabelsi,1 Mejda Bouladi,2 Amel Ouertani,1 Ahmed Trabelsi1 1Clinique Ophtalmologique de Tunis, Tunis, Tunisia; 2Department of Surgery, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaCorrespondence: Mejda Bouladi, Faculty ...
Trabelsi O, Bouladi M, Ouertani A, Trabelsi A   +3 more
doaj  

The Role of Thrombin in Proliferative Vitreoretinopathy

Investigative Opthalmology & Visual Science, 2014
To determine the role of thrombin in the development of proliferative vitreoretinopathy (PVR).Vitreous was collected from patients undergoing a vitrectomy (macular holes and puckers, n = 11 [controls]; retinal detachment without PVR development following vitrectomy, n = 15 [RRD1]; retinal detachment with PVR development within 6 months after vitrectomy,
Jeroen Bastiaans, Jan C. van Meurs, Marja Smits-Te Nijenhuis, Verena C. Mulder, Herbert Hooijkaas, Willem A. Dik, B. C. M. Dufour-van den Goorbergh, Nicole M A Nagtzaam, P. Martin van Hagen   +8 more
openaire   +3 more sources

Myo/Nog Cells Give Rise to Myofibroblasts During Epiretinal Membrane Formation in a Mouse Model of Proliferative Vitreoretinopathy. [PDF]

, 2023
PURPOSE: Myo/Nog cells are the source of myofibroblasts in the lens and synthesize muscle proteins in human epiretinal membranes (ERMs). In the current study, we examined the response of Myo/Nog cells during ERM formation in a mouse model of ...
Abdalla, Fathma, Bravo Nuevo, Arturo, Crispin, Mara, George-Weinstein, Mindy, Gerhart, Jacquelyn, Heffer, Alison, Kuriyan, Ajay E, Martin, Mark, Philp, Nancy J   +8 more
core   +1 more source

Vitreoschisis‐induced vitreous cortex remnants in proliferative vitreoretinopathy: A comprehensive review from basic research to clinical practice

Acta Ophthalmologica, Volume 102, Issue 8, Page 859-880, December 2024.
Abstract Proliferative vitreoretinopathy (PVR) significantly impacts the prognosis of rhegmatogenous retinal detachment (RRD), one of the most critical and increasing causes of vision loss in the Western world. Despite advancements in surgical instruments and techniques, the failure rate due to PVR remains substantial, necessitating additional ...
Koen A. van Overdam, Marc Veckeneer, Emine Kiliç, Peter G. van Etten, Jerry Sebag, Jan C. van Meurs   +5 more
wiley   +1 more source

Proliferative vitreoretinopathy: current and emerging treatments

Clinical Ophthalmology, 2012
Ama Sadaka,1 Gian Paolo Giuliari2,31Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; 2Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela; 3Department of Ophthalmology, Domingo Luciani ...
Sadaka A, Giuliari GP
doaj