Results 61 to 70 of about 146,300 (194)

Outcomes and complications of primary rhegmatogenous retinal detachment repair with pars plana vitrectomy in young adults

International Journal of Retina and Vitreous, 2023
Background Scleral buckling has been the standard for rhegmatogenous retinal detachment repair in young patients given the typical lack of posterior vitreous detachment, phakic status, and lower risk of proliferative vitreoretinopathy. In older patients,
Venkatkrish M. Kasetty, Jennifer Aye, Nish Patel, Nitika Tripathi, Thomas Hessburg, Nitin Kumar, Uday R. Desai, Abdualrahman E. Hamad   +7 more
doaj   +1 more source

Construction and Validation of a Long‐Term Visual Prognosis Prediction Model for Proliferative Diabetic Retinopathy After Vitrectomy Based on Machine Learning

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
This study developed and validated a machine learning‐based prognostic model for predicting long‐term visual outcomes after pars plana vitrectomy (PPV) in patients with proliferative diabetic retinopathy. ABSTRACT Introduction This study aims to develop a machine‐learning‐based risk prediction model for a long‐term visual prognosis in patients with ...
Xiaolu Wang, Jinghua Shi, Yan Gao, Tiantian Li, Xuehong Han, Lixia Guo, Tingting Jia, Yan Wang   +7 more
wiley   +1 more source

A Rare Case of Lens-Induced Uveitis with Proliferative Vitreoretinopathy and Massive Encapsulation of Fallen Nuclear Material

Case Reports in Ophthalmology, 2020
We experienced a rare case of lens-induced uveitis (LIU) with severe proliferative vitreoretinopathy (PVR) diagnosed upon finding lens nuclear material encapsulated by intravitreal proliferative tissue.
Saki Inoue, Hisanori Imai, Akira Tetsumoto, Keiko Otsuka, Makoto Nakamura   +4 more
doaj   +1 more source

Current Landscape and Future Perspectives of Diabetic Retinopathy Therapy: Pharmacological Targets, Precision Laser Technology, and Clinical Evidence

MedComm, Volume 7, Issue 7, July 2026.
Targeted biological agents targeting VEGF, integrin, dopamine D2 receptor, ROCK, and BCL‐XL have entered the clinical trial phase and deserve particular attention. The treatment paradigm has shifted toward personalized and precision medicine, positioning optimized SML as a promising adjunctive therapy.
Xinying Hu, Zhe Cha, Ao Lu, Wuping Xu, Xiaoqing Zhang, Sheng Miao, Haiwei Xu, Xuedong Xu   +7 more
wiley   +1 more source

Proliferative vitreoretinopathy: an update on the current and emerging treatment options. [PDF]

Proliferative vitreoretinopathy (PVR) remains the main cause of failure in retinal detachment (RD) surgery and a demanding challenge for vitreoretinal surgeons.
Ferro Desideri, Lorenzo, Artemiev, Dmitri, Zandi, Souska, Zinkernagel, Martin S, Anguita, Rodrigo   +4 more
core   +2 more sources

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Proliferative vitreoretinopathy: current and emerging treatments

Clinical Ophthalmology, 2012
Ama Sadaka,1 Gian Paolo Giuliari2,31Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; 2Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela; 3Department of Ophthalmology, Domingo Luciani ...
Sadaka A, Giuliari GP
doaj  

Research Progress on Anti‐Inflammatory Adipokine SFRP5‐Mediated Lipid Metabolism and Its Potential Role in Neural Development

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Objective To systematically review the structural features of secreted frizzled‑related protein 5 (SFRP5) and its dual regulation of canonical/non‑canonical Wnt signaling, analyze its association with metabolic disorders, and specifically explore the role and mechanisms of the SFRP5–lipid metabolism axis in neural and optic nerve development ...
Qianfang Jia, Zihan Li, Tianyi Yang, Weihua Yang, Wei Chi   +4 more
wiley   +1 more source

Animal Models of Proliferative Vitreoretinopathy and Their Use in Pharmaceutical Investigations

, 2018
Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research.
Eric Nudleman, Huiyuan Hou, Robert N. Weinreb   +2 more
core   +1 more source

Phenotypic Refinement of ESAM‐Related Tight‐Junctionopathy: Novel Genetic and Ocular Findings and Literature Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
Overview of neurological, ocular, and genetic findings in individuals with bi‐allelic loss‐of‐function (LoF) ESAM variants. All affected subjects (n = 21) exhibited characteristic neurovascular and neurodevelopmental anomalies, while 45% also showed ocular (mainly retinal) involvement.
Mauro Lecca, Chiara Bosetti, Federico Ruoli, Liviana Fontanel, Marco Mazza, Enza Maria Valente, Roberta Battini, Edoardo Errichiello   +7 more
wiley   +1 more source