Results 51 to 60 of about 146,300 (194)

Pathophysiology of proliferative vitreoretinopathy in retinal detachment

, 2013
Because proliferative vitreoretinopathy cannot be effectively treated, its prevention is indispensable for the success of surgery for retinal detachment. The elaboration of preventive and therapeutic strategies depends upon the identification of patients
Garweg, Justus G., Halberstadt, Markus, Tappeiner, Christoph, Garweg, Justus, Halberstadt M, Garweg JG, Tappeiner C   +6 more
core   +1 more source

Anatomic Success of Scleral Buckling for Rhegmatogenous Retinal Detachment - A Retrospective Study of 524 Cases [PDF]

, 2010
Background/Aim: Our purpose was to investigate the anatomic success of scleral buckling surgery for rhegmatogenous retinal detachment. Material and Methods: A total of 524 consecutive patients were retrospectively analysed.
Haritoglou, Christos, Priglinger, Siegfried G., Brandlhuber, Ulrich, Kampik, Anselm   +3 more
core   +1 more source

Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice

Nature Communications
Proliferative vitreoretinopathy is a vision-threatening response to penetrating ocular injury, for which there is no satisfactory treatment. In this disorder, retinal pigment epithelial cells, abandon their attachment to Bruch’s membrane on the scleral ...
Min Luo, Dena Almeida, Valentina Dallacasagrande, Nadia Hedhli, Mrinali Gupta, Donald J. D’Amico, Szilárd Kiss, Katherine A. Hajjar   +7 more
doaj   +1 more source

Non-surgical interventions for proliferative vitreoretinopathy-a systematic review. [PDF]

Eye (Lond)
Proliferative Vitreoretinopathy (PVR) is the most common cause of surgical failure after retinal detachment (RD) repair, complicating up to 10% of spontaneous RD repairs and 50% of open globe injury-related RD.
Hunter G, Maclean N, Watson S, Colyer M, Leong J, Agrawal R, McClellan SF, Miller KE, Woreta FA, Caldwell MC, Williamson T, Gensheimer W, Cavuoto K, Hoskin AK, Rousselot Ascarza A, Dhawahir-Scala WGF, Sundar G, Mazzoli RA, Shah P, Woodcock M, Kuhn F, Gomes RS, Justin GA, Blanch RJ.   +23 more
europepmc   +2 more sources

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, Volume 15, Issue 39, 23 October 2026.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

A Novel De Novo Heterozygous Missense Variant in CTNNB1 (c.2215A>C, p.Met739Leu) Underlying Neurodevelopmental Disorder With Spastic Diplegia and Visual Defects (NEDSDV): A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT We report a 7‐year‐old male with microcephaly, spasticity, strabismus, dysmorphism, autistic behaviors, and moderate ID due to a novel de novo likely pathogenic CTNNB1 variant (c.2215A>C, p.Met739Leu). This case underscores Whole Exome Sequencing's diagnostic utility for early detection of rare monogenic neurodevelopmental disorders.
Omar Jamal Ibrahim, Ali Rajabi, Mortaza Bonyadi, Mohammad Barzegar   +3 more
wiley   +1 more source

Epithelial Membrane Protein-2 in Human Proliferative Vitreoretinopathy and Epiretinal Membranes. [PDF]

, 2016
PurposeTo determine the level of epithelial membrane protein-2 (EMP2) expression in preretinal membranes from surgical patients with proliferative vitreoretinopathy (PVR) or epiretinal membranes (ERMs).
Telander, David G, Yu, Alfred K, Forward, Krisztina I, Morse, Lawrence S, Park, Susanna S, Gordon, Lynn K, Morales, Shawn A   +6 more
core   +1 more source

Effect of etanercept on post-traumatic proliferative vitreoretinopathy [PDF]

International Journal of Ophthalmology, 2019
AIM: To evaluate the safety and efficacy of intravitreal etanercept in the inhibiting of proliferative vitreoretinopathy (PVR) in a model of penetrating ocular injury.
Xiao-Feng Chen, Mei Du, Xiao-Hong Wang, Hua Yan   +3 more
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, Volume 13, Issue 54, 28 September 2026.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Syntaxin‐3 Regulates Tight Junction Assembly in Human Retinal Pigment Epithelium

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The retinal pigment epithelium (RPE) consists of polarized epithelial cells, serving as a support system for photoreceptor maintenance, where the polarity is contributed by the distribution of syntaxins (STX) within the cell. STX3, a known regulator of apical trafficking in epithelial cells, was previously understood to be absent in human RPE ...
Athira Ramesh, Suganya Sivagurunathan, Navya Valavath Baburajan, Subbulakshmi Chidambaram   +3 more
wiley   +1 more source