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Microbiota Alterations in Proline Metabolism Impact Depression [PDF]
Cell Metabolism, 2022 Aminoàcids; Depressió; MicrobiotaAminoácidos; Depresión; MicrobiotaAmino acids; Depression; MicrobiotaThe microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with low treatment efficacy.
Mariona Jové, Miquel Martin
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Amino Acids, 2021
Cancer cells often change their metabolism to support uncontrolled proliferation. Proline is the only proteogenic secondary amino acid that is abundant in the body. Recent studies have shown that proline metabolism plays an important role in metabolic reprogramming and affects the occurrence and development of cancer.
Guowang Xu, Wangshu Qin, Pengyu Geng
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Cancer cells often change their metabolism to support uncontrolled proliferation. Proline is the only proteogenic secondary amino acid that is abundant in the body. Recent studies have shown that proline metabolism plays an important role in metabolic reprogramming and affects the occurrence and development of cancer.
Guowang Xu, Wangshu Qin, Pengyu Geng
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Targeting Proline Metabolism? [PDF]
Nature Reviews Cancer, 2016 Gemma K Alderton
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The Metabolism of Proline as Microenvironmental Stress Substrate. [PDF]
Journal of Nutrition, 2008 Proline, a unique proteogenic secondary amino acid, has its own metabolic system with special features. Recent findings defining the regulation of this system led us to propose that proline is a stress substrate in the microenvironment of inflammation and tumorigenesis.
Jui Pandhare, Yongmin Liu
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Metabolism of Proline and the Hydroxyprolines
Annual Review of Biochemistry, 1980PERSPECTIVES AND SUMMARY 1006 INTRODUCTION 1007 PROLINE 1008 Proline Biosynthesis: The Glutamate Pathway 1008 Proline Biosynthesis: The Om Pathway 1015 Proline Degradation: The P5C Pathway 1018 Proline Degradation: Reguiation 1020 Proline Degradation: Other Pathways 1023 4-HYDROXYPROLlNE 1024 Natural Occurrence 1024 Metabolism ...
E, Adams, L, Frank
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Proline metabolism in cartilage: The importance of proline biosynthesis
Metabolism, 1978Abstract Mammalian cells have the capacity to synthesize proline from ornithine or glutamic acid, although preformed proline usually is available from extracellular sources. We have measured the rate of proline formation from ornithine in the presence of physiologic concentrations of proline. In rat xiphoid cartilage organ cultures with ornithine and
R J, Smith, J M, Phang
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Effect of Dietary Proline on Proline Metabolism in the Neonatal Pig
The Journal of Nutrition, 1989The effect of two dietary concentrations of proline (10.3 and 15.8 g/kg) on proline-metabolizing enzymes [pyrroline-5-carboxylate (P5C) reductase and proline oxidase], plasma and tissue free proline concentrations and growth were investigated in the 2- to 13-d-old pig. Diet had no effect on growth or enzyme activity. Diet had a significant (P less than
S E, Samuels, H L, Aarts, R O, Ball
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Amino Acids, 1997
Sepsis is characterized by an abnormal increase in plasma proline (PRO) level, which tends to be related to the severity of disease. This study has been performed to assess the relationship between changes in plasma PRO and levels and doses of other amino acids (AA) in critically ill septic patients undergoing total parenteral nutrition (TPN).
Chiarla C +6 more
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Sepsis is characterized by an abnormal increase in plasma proline (PRO) level, which tends to be related to the severity of disease. This study has been performed to assess the relationship between changes in plasma PRO and levels and doses of other amino acids (AA) in critically ill septic patients undergoing total parenteral nutrition (TPN).
Chiarla C +6 more
openaire +1 more source
Proline metabolism in Leishmania tarentolae
Experimental Parasitology, 1969Abstract Leptomonads of Leishmania tarentolae were able to grow in Trager's defined medium C deficient in glucose or l -proline, but not without both. In addition, inositol and glycine could be deleted without any adverse effect as long as either glucose or l -proline was present.
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2004
Besides their function as building blocks for proteins, certain amino acids have other important physiological roles. Such is the case of the non-polar imino acid proline and of lysine, a basic amino acid. Proline is accumulated by bacterial cells during osmotic stress as one of the prevalent compatible solutes that act as osmoprotectants21, 39.
Olga Revelles, Manuel Espinosa-Urgel
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Besides their function as building blocks for proteins, certain amino acids have other important physiological roles. Such is the case of the non-polar imino acid proline and of lysine, a basic amino acid. Proline is accumulated by bacterial cells during osmotic stress as one of the prevalent compatible solutes that act as osmoprotectants21, 39.
Olga Revelles, Manuel Espinosa-Urgel
openaire +1 more source