Results 271 to 280 of about 195,829 (321)

Time‐ and cultivar‐dependent biochemical responses to heat priming and stress in rice

Annals of Applied Biology, EarlyView.
Global warming increasingly threatens rice productivity, and understanding the biochemical mechanisms underlying heat stress responses is crucial for developing resilient cultivars. By demonstrating that stress responses are both cultivar‐ and time‐of‐day‐dependent, our findings offer new insights into the temporal and genetic regulation of acquired ...
Luana Ramos dos Santos, Victória Carvalho, Cristiane Paula Gomes Calixto   +2 more
wiley   +1 more source

Effects of dopamine on reducing salt stress damage in pepper (Capsicum annuum L.) at morphological, physiological, biochemical, and molecular levels

Annals of Applied Biology, EarlyView.
Salt stress causes oxidative and osmotic stress, resulting in decreased nutrient uptake, plant growth, and photosynthetic rate. This study suggests that foliar application of dopamine can reduce salinity‐induced oxidative damage in pepper plants by altering antioxidant activity, biochemical, and molecular responses.
Sumeyra Ucar, Esra Yaprak, Melek Ekinci, Merve Yuce, Murat Aydin, Metin Turan, Esma Yigider, Guleray Agar, Melike Akca, Simona Ioana Vicas, Ertan Yildirim   +10 more
wiley   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Dysregulated proline metabolism exacerbates HCC metastasis via EPRS1-mediated mRNA translation

Haitao Zhang, Leirong Gu, Xiameng Su, Wanjin Chen, Ming Tan, Haibo Yu, Hongzhong Zhou, Tingting Gao, Zhiling Wang, Xinyan Chen, W-Z Chen, Juan Chen, Shengtao Cheng   +12 more
openalex   +1 more source

[Some problems of proline metabolism].

Postepy biochemii, 1968
openaire   +1 more source