Results 111 to 120 of about 222,440 (323)

Research needs related to the care of patients on prolonged mechanical ventilation [PDF]

, 2011
Mary Beth Happ, Leslie A. Hoffman
openalex   +1 more source

Multicenter Validation of the Vasoactive-Ventilation-Renal Score as a Predictor of Prolonged Mechanical Ventilation After Neonatal Cardiac Surgery*

Pediatric Critical Care Medicine, 2018
Objectives: We sought to validate the Vasoactive-Ventilation-Renal score, a novel disease severity index, as a predictor of outcome in a multicenter cohort of neonates who underwent cardiac surgery. Design: Retrospective chart review.
Katherine Cashen, J. Costello, Lisa M. Grimaldi, K. M. Narayana Gowda, E. Moser, K. Piggott, M. Wilhelm, C. Mastropietro   +7 more
semanticscholar   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Diastolic dysfunction is common and predicts outcome after cardiac surgery

Journal of Cardiothoracic Surgery, 2018
Background Diastolic dysfunction (DD) identified on echocardiography predicts mortality after cardiac surgery, however the most useful diastolic parameters for assessment and the association of DD with prolonged mechanical ventilation, ICU re-admission ...
Thomas S. Metkus, Alejandro Suarez-Pierre, Todd C. Crawford, Jennifer S. Lawton, Lee Goeddel, Jeffrey Dodd-o, Monica Mukherjee, Theodore P. Abraham, Glenn J. Whitman   +8 more
doaj   +1 more source

[Prolonged mechanical ventilation following heart surgery].

Arquivos brasileiros de cardiologia, 1994
To study the causes of difficulty or impossible weaning of cardiac surgical patients undergoing mechanical ventilation in the postoperative period and their outcome.Three hundred and forty three consecutive adult patients submitted to open heart surgery were retrospectively studied and classified in three groups: I--patients in mechanical ventilation ...
F S, Dias, G, Milius, A A, Posenato, D V, Palombini, L C, Bodanese, J B, Petracco   +5 more
openaire   +2 more sources

Kinetics of oxygen uptake during unassisted breathing trials in prolonged mechanical ventilation: a prospective pilot study [PDF]

, 2020
Ivan Lee, Yao-Wen Kuo, Feng-Ching Lin, Changwei Wu, Jih‐Shuin Jerng, Ping‐Hung Kuo, Jui-Chen Cheng, Ying‐Chun Chien, Chun‐Kai Huang, Huey‐Dong Wu   +9 more
openalex   +1 more source

Prolonged mechanical ventilation and caregiver strain: Home vs. long-term care facility [PDF]

, 2022
Esther-Lee Marcus, Jeremy M. Jacobs, Jochanan Stessman   +2 more
openalex   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Mechanical Ventilation Weaning in Inclusion Body Myositis: Feasibility of Isokinetic Inspiratory Muscle Training as an Adjunct Therapy

Case Reports in Critical Care, 2014
Inclusion body myositis is a rare myopathy associated with a high rate of respiratory complications. This condition usually requires prolonged mechanical ventilation and prolonged intensive care stay.
Leonardo Cordeiro de Souza, Josué Felipe Campos, Leandro Possidente Daher, Priscila Furtado da Silva, Alex Ventura, Pollyana Zamborlini do Prado, Daniele Brasil, Debora Mendonça, Jocemir Ronaldo Lugon   +8 more
doaj   +1 more source