Results 131 to 140 of about 87,591 (293)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

open access: yesAdvanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu   +12 more
wiley   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

open access: yesAdvanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun   +14 more
wiley   +1 more source

Early mobilization of LVAD recipients who require prolonged mechanical ventilation

open access: yes, 2006
Early mobilization and aggressive physical therapy are essential in patients who receive left ventricular assist devices (LVADs) due to long-term, end-stage heart failure.
Southard, Robert E   +4 more
core  

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

open access: yesAdvanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim   +5 more
wiley   +1 more source

Prolonged Mechanical Ventilation (PMV) in Adult Patients in ICU (Definitions and Factors): a Scoping Review

open access: yes
Prolonged Mechanical Venilation (PMV) in the Intensive Care Unit can cause several problems including causing various diseases that are not expected, increasing the length of stay (LOS) of patients which ultimately increases the cost of care.This study ...
Kosasih, Cecep E   +2 more
core   +1 more source

A comparative study on prolonged endotracheal intubation versus tracheostomy in toxicology ICU patients requiring prolonged mechanical ventilation [PDF]

open access: yes, 2018
AIM OF THE STUDY: To study the effectiveness of tracheostomy in reducing duration of ventilation and hospital stay and to study the complications associated with tracheostomy and endotracheal intubation.And also to define optimum time to carry out ...
Parimala Devi, G
core  

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta‐Analysis

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Esophagectomy remains a highly invasive procedure associated with substantial postoperative morbidity. Pulmonary complications, anastomotic leakage, and in‐hospital mortality are of particular concern. Perioperative corticosteroids are often administered to attenuate excessive inflammatory responses; however, the clinical impact in ...
Tomohiko Yasuda   +4 more
wiley   +1 more source

Demographic and Clinical Risk Factors Contributing to Prolonged Mechanical Ventilation in ICU Patients at Tenwek Hospital

open access: yes
Prolonged mechanical ventilation (PMV) remains a significant clinical challenge in intensive care units (ICUs). Approximately 30% of ventilated patients require PMV with attendant risk for higher morbidity, mortality, and healthcare expenditure. In spite
Nyangena, Elijah Nyabuti   +2 more
core   +1 more source

Risks and Benefits of Feeding Enterostomy Creation During Minimally Invasive Esophagectomy: A Propensity‐Weighted Analysis Using the Japanese National Clinical Database

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Feeding enterostomy during MIE was evaluated in 19 054 patients from the Japanese NCD using propensity weighting. Enterostomy was associated with higher reoperation and respiratory complications, but lower delayed gastric emptying and deep vein thrombosis, with no significant difference in overall bowel obstruction.
Eisuke Booka   +7 more
wiley   +1 more source

Tracheostomy care and outcomes in a tertiary care hospital in Sikkim- An observational study [PDF]

open access: yesAl Ameen Journal of Medical Sciences
Background: Tracheostomy is life saving in patients with neurological deficits, coma or facial trauma as it provides access for clearing the retained secretions and facilitates prolonged mechanical ventilation (MV).
Priyadarsini T   +4 more
doaj  

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