Results 171 to 180 of about 146,778 (328)

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

Fatores preditores independentes de ventilação mecânica prolongada em pacientes submetidos à cirurgia de revascularização miocárdica Independent predictors of prolonged mechanical ventilation after coronary artery bypass surgery

Brazilian Journal of Cardiovascular Surgery, 2012
OBJETIVO: Determinar os fatores preditores independentes de ventilação mecânica prolongada em pacientes submetidos à cirurgia de revascularização miocárdica.
Raquel Ferrari Piotto, Fabricio Beltrame Ferreira, Flávia Cortez Colósimo, Gilmara Silveira da Silva, Alexandre Gonçalves de Sousa, Domingo Marcolino Braile   +5 more
doaj  

Aerospace Medicine and Biology: A continuing bibliography with indexes (supplement 133) [PDF]

This special bibliography lists 276 reports, articles, and other documents introduced into the NASA Scientific and Technical Information System in September ...

core   +1 more source

Cyclic Strain and Macrophage‐Mediated Transport Govern Micron‐Sized PM2.5 Translocation across the Air–Blood Barrier

Advanced Science, EarlyView.
Using a dynamic, tri‐culture air‐blood barrier model, this study reveals that macrophage‐mediated transport governs micron‐sized particle translocation under cyclic strain. The process is highly size‐dependent that 2 µm particles are transported by macrophages, 0.2 µm particles diffuse passively, and 5 µm particles are effectively blocked.
Yongjian Li, Jinlong Xu, Zujie Gao, Haosheng Chen   +3 more
wiley   +1 more source

Nature‐Inspired Innovation in Electrical Engineering Technologies and Applications

Advanced Science, EarlyView.
This review investigates how nature‐inspired design principles revolutionize electrical engineering by translating biological mechanisms, such as sensing, actuation, energy conversion, and neural processing, into advanced intelligent technologies. Through interdisciplinary integration, biomimetic strategies enable efficient, adaptive, and sustainable ...
Ming Li, Anran Mao, Qingwen Guan, Yang Xu, Chang Li, Gang Lu, Eduardo Saiz   +6 more
wiley   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Assessment the effectiveness of the integrated care demonstration program for ventilator dependent patients in Taiwan

International Journal of Integrated Care, 2013
S.I. Wang, H.C. Chiang
doaj   +3 more sources

Mechanosensitive Piezo1 Channels Mediate Diaphragm Fibrosis Induced by Prolonged Mechanical Ventilation. [PDF]

J Cachexia Sarcopenia Muscle
Xie D, Xiao Y, Li X, Sun B, Feng J, Jia J, Li J, Wang Y, He F, Liu L.   +9 more
europepmc   +1 more source

A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation*

, 2011
Shannon S. Carson, Jeremy M. Kahn, Catherine L. Hough, Eric J. Seeley, Douglas B. White, Ivor S. Douglas, Christopher E. Cox, Ellen Caldwell, Shrikant I. Bangdiwala, Joanne M. Garrett, Gordon D. Rubenfeld   +10 more
openalex   +2 more sources

Pulmonary‐Targeted Nanoparticles Interrupt the Malignant Mechanical and Biochemical Signaling Crosstalk for Idiopathic Pulmonary Fibrosis Therapy

Advanced Science, EarlyView.
Idiopathic pulmonary fibrosis (IPF) progression is driven by TGF‐β induced biochemical signals and mechanical signals from increased ECM stiffness. Pulmonary‐targeted VB‐RT NPs not only eliminate excessive ROS and penetrate the dense ECM collagen barrier via NO release, but also simultaneously interrupt the persistent malignant between mechanical and ...
Xue‐Na Li, Ya‐Ping Lin, Xi‐Xi Ma, Yue‐Fei Fang, Hui Wang, Chun‐Hui Cui, Chen Zhang, Jin‐You Piao, Jee‐Heon Jeong, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +11 more
wiley   +1 more source