Results 111 to 120 of about 111,832 (326)

A case of hypoglycemiainduced QT prolongation leading to torsade de pointes and a review of pathophysiological mechanisms

Clinics and Practice, 2017
Torsades de pointes is a life-threatening cardiac arrhythmia. Occurrence of this arrhythmia as a result of hypoglycemia has not been reported in the literature.
Faris Hannoodi, Hashim Alwash, Kushal Shah, Israa Ali, Sarwan Kumar, Khalid Zakaria   +5 more
doaj   +1 more source

Sustained-Release Bupropion Overdose: A Case Report [PDF]

, 2015
Bupropion is an atypical antidepressant with a unique aminoketone structure similar to amphetamines. A narrow therapeutic margin is evident from observational studies that show seizure activity with doses of 400-600 mg or higher.
Aragão, I., Meireles, J., Mendonça, C., Pestana, P., Rocha, S., Teixeira, C.   +5 more
core   +1 more source

Drug‐Induced QT Prolongation: Associations Between Risk Classifications in a Swedish Clinical Decision Support System and Clinical Outcomes

Clinical Pharmacology &Therapeutics, EarlyView.
Potential adverse drug events can be signaled in Clinical Decision Support Systems (CDSSs). This study validated a Swedish CDSS (Janusmed Risk Profile) by investigating associations between calculated risk classifications of drugs with QT‐prolonging potential and registered related clinical outcomes.
Ola Nordqvist, Olof Björneld, Patrick Bergman, Björn Wettermark, Alisa Lincke, Marine L. Andersson, Tora Hammar   +6 more
wiley   +1 more source

Linkage Evidence for a Two-Locus Inheritance of LQT-Associated Seizures in a Multigenerational LQT Family With a Novel KCNQ1 Loss-of-Function Mutation [PDF]

, 2019
Mutations in several genes encoding ion channels can cause the long-QT (LQT) syndrome with cardiac arrhythmias, syncope and sudden death. Recently, mutations in some of these genes were also identified to cause epileptic seizures in these patients, and
Gessner, Guido, Heinemann, Stefan H., Prüss, Harald, Rimpau, Wilhelm, Ruppert, Ann-Katrin, Rüschendorf, Franz, Sander, Thomas, Schulz, Herbert   +7 more
core   +2 more sources

Comparison of Four Rate-Correction Algorisms for the Ventricular Repolarization Period in Assessing Net Effects of IKr Blockers in Dogs

Journal of Pharmacological Sciences, 2006
The utility of corrected and uncorrected QT interval changes for assessing net repolarization delay by IKr (a rapid component of delayed rectifier K+ currents) blockers was assessed in halothane-anesthetized dogs using the electrocardiogram and ...
Akira Takahara, Atsushi Sugiyama, Yoshioki Satoh, Keitaro Hashimoto   +3 more
doaj   +1 more source

Natural entropy fluctuations discriminate similar looking electric signals emitted from systems of different dynamics

, 2005
Complexity measures are introduced, that quantify the change of the natural entropy fluctuations at different length scales in time-series emitted from systems operating far from equilibrium. They identify impending sudden cardiac death (SD) by analyzing
A. L. Goldberger, A. L. Goldberger, E. S. Skordas, J. S. Richman, M. S. Lazaridou, N. V. Sarlis, P. A. Varotsos, P. A. Varotsos, P. A. Varotsos, P. Laguna, P. Varotsos, R. Jané   +11 more
core   +1 more source

Methadone and Corrected QT Prolongation in Pain and Palliative Care Patients: A Case–Control Study [PDF]

, 2017
Background: Methadone (ME) is commonly used in pain and palliative care (PPC) patients with refractory pain or intolerable opioid adverse effects (AEs).
Brown, Jack, Hutchinson, David, Juba, Katherine, Khadem, Tina M.   +3 more
core   +2 more sources

Global patterns of polypharmacy after acute heart failure hospitalization: Prevalence and outcomes from the REPORT‐HF registry

European Journal of Heart Failure, EarlyView.
Global patterns of polypharmacy after acute heart failure hospitalization. GDMT, guideline‐directed medical therapy; HF, heart failure. Aims Polypharmacy, defined as the concurrent use of ≥5 medications, is prevalent among older adults with heart failure (HF).
Wan Ting Tay, Tiew‐Hwa Katherine Teng, Wouter Ouwerkerk, John G.F. Cleland, Sean P. Collins, Christiane E. Angermann, Kenneth Dickstein, Ulf Dahlstrom, Anja Schweizer, Achim Obergfell, Kai‐Hang Yiu, Mathieu Ghadanfar, Mahmoud Hassanein, Qing‐Wen Ren, Wen‐Li Gu, Georg Ertl, Sergio V. Perrone, Gerasimos Filippatos, Carolyn S.P. Lam, Jasper Tromp   +19 more
wiley   +1 more source

Evaluation of Ventricular Repolarisation Features with Novel Electrocardiographic Parameters in Patients with Severe Periodontitis

İstanbul Medical Journal, 2020
Introduction:Ventricular arrhythmic predictors in severe periodontitis may be linked with cardiovascular events and the sudden death risk. In this study, we evaluated certain electrocardiographic (ECG) ventricular arrhythmic predictors in patients with ...
Mehmet İnanır, Emrah Erdal, Gülbahar Ustaoğlu, İsa Sincer   +3 more
doaj   +1 more source

Genotype-Phenotype Relationships in Long QT Syndrome : Role of Mental Stress, Adrenergic Activity and a Common KCNH2 Polymorphism [PDF]

, 2006
Long QT syndrome is a congenital or acquired arrhythmic disorder which manifests as a prolonged QT-interval on the electrocardiogram and as a tendency to develop ventricular arrhythmias which can lead to sudden death.
Paavonen, Kristian
core