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The Journal of Physiology, EarlyView.Abstact figure legend A panoramic 3D optical mapping system was developed, enabling imaging of action potential waves across the entire strongly deforming ventricular surface of beating isolated hearts. The system comprises 12 high‐speed cameras and a soccerball‐shaped imaging chamber with 48 light‐emitting diodes (LEDs).
Shrey Chowdhary +5 more
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Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin
The Journal of Physiology, EarlyView.Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George +5 more
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The Journal of Physiology, EarlyView.Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato +3 more
wiley +1 more source
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Hypocalcemia-Induced QT Interval Prolongation
Cardiology, 2022An 87-year-old man with a history of transcatheter aortic valve replacement, pulmonary hypertension, diastolic dysfunction with preserved systolic function, and myelofibrosis had a 12-lead ECG showed a prolonged QT interval of 508 ms with heart-rate correction placing it in the 99th percentile of the population.
Jacky K.K. Tang, Simon W. Rabkin
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The Journal of Emergency Medicine, 1985
The QT interval is a function of ventricular repolarization time and is measured from the onset of the QRS complex to the end of the T wave. The length of this interval is inversely related to heart rate. A prolonged QT interval is most often secondary to the use of Type I antidysrhythmic medications (quinidine, procainamide).
J L, Scott, R M, Walls
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The QT interval is a function of ventricular repolarization time and is measured from the onset of the QRS complex to the end of the T wave. The length of this interval is inversely related to heart rate. A prolonged QT interval is most often secondary to the use of Type I antidysrhythmic medications (quinidine, procainamide).
J L, Scott, R M, Walls
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Syncope With Prolonged QT Interval
Archives of Pediatrics & Adolescent Medicine, 1976Four children with syncope had a prolonged QT interval on the electrocardiogram. Neurologic studies were negative. One patient had associated deaf mutism, one had a family history of sudden death and prolonged QT interval, and two had ventricular arrhythmias while being monitored in the hospital.
J P, Frank, D Z, Friedberg
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Gatifloxacin and Prolonged QT Interval
The American Journal of the Medical Sciences, 2004We report the case of a 54-year-old woman who, while being treated for acute sinusitis with gatifloxacin, presented with syncope and was found to have a markedly prolonged QT interval. After stopping gatifloxacin, the QT interval normalized. We speculate that her episode of syncope was caused by a ventricular arrhythmia that resulted from an increased ...
Shoaib R, Ansari, Nagesh, Chopra
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Prolongation of the QT interval in primary aldosteronism
Clinical and Experimental Pharmacology and Physiology, 2005SUMMARY1. Only limited information is available concerning the changes in the electrocardiogram in primary aldosteronism. The aim of the present study was to determine factors influencing the QTc interval in patients with primary aldosteronism.2. Nineteen patients with primary aldosteronism caused by a Conn's adenoma and 69 patients with essential ...
Kiyoshi, Matsumura +4 more
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Antipsychotic Drugs and QT Interval Prolongation
Psychiatric Quarterly, 2003The QTc prolongation by antipsychotic drugs is of major concern, especially in light of the data indicating an increased risk of sudden death in psychiatric patients taking these drugs. Sudden death in psychiatric patients could be partially attributed to drug-induced torsades de pointes and for this reason careful evaluation of QTc prolonging ...
Wojciech, Zareba, David A, Lin
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Prolonged QT-Interval Syndromes
JAMA: The Journal of the American Medical Association, 1986PROLONGATION of the QT interval, either on a congenital or an acquired basis, is associated with an increased likelihood of malignant ventricular arrhythmias. 1-3 Patients with QT prolongation frequently develop recurrent attacks of syncope or may present with sudden death.
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