Results 51 to 60 of about 113,542 (365)

Sensitivity of inhalation anesthetics isoflurane and sevoflurane for the drug-induced QT-interval prolongation in guinea pigs

open access: yesJournal of Pharmacological Sciences, 2020
We investigated effects of isoflurane and sevoflurane on sparfloxacin-induced QT-interval prolongation in guinea pigs under the monitoring of electrocardiogram and monophasic action potential (MAP), which was compared with those of halothane or non ...
Yoshinobu Nagasawa   +5 more
doaj   +1 more source

Effect of Hydroxychloroquine and Azithromycin on QT Interval Prolongation and Other Cardiac Arrhythmias in COVID-19 Confirmed Patients

open access: yesCardiovascular Therapeutics, 2021
Background. Hydroxychloroquine with or without azithromycin was one of the common therapies at the beginning of the COVID-19 pandemic. They can prolong QT interval, cause torsade de pointes, and lead to sudden cardiac death.
Seyed Parsa Eftekhar   +5 more
doaj   +1 more source

Electrocardiographic Screening for Prolonged QT Interval to Reduce Sudden Cardiac Death in Psychiatric Patients: A Cost-Effectiveness Analysis

open access: yesPLoS ONE, 2015
Importance Sudden cardiac death is a leading cause of mortality in psychiatric patients. Long QT (LQT) is common in this population and predisposes to Torsades-de-Pointes (TdP) and subsequent mortality.
A. Poncet   +8 more
semanticscholar   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

open access: yesThe Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi   +21 more
wiley   +1 more source

Epicardial adipose tissue predicted prolonged QTc interval in patients with arterial hypertension

open access: yesClinical and Experimental Hypertension, 2021
Introduction: It is important to identify those at higher risk for ventricular arrhythmia among hypertensive patients. Epicardial adipose tissue (EAT) leads to electromechanical changes in the heart by endocrine and paracrine effects with cytokines and ...
Ahmet Seyda Yılmaz   +3 more
doaj   +1 more source

A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs [PDF]

open access: yes, 2016
© 2016 Elsevier Ireland Ltd Background The interaction between the PTa and PP interval dynamics from the surface ECG is seldom explained. Mathematical modeling of these intervals is of interest in finding the relationship between the heart rate and ...
Langley, Philip   +5 more
core   +1 more source

Dual‐Ligand Metal‐Organic Frameworks via In Situ Amidoxime Engineering for Selective Ion Separation

open access: yesAdvanced Functional Materials, EarlyView.
Inspired by microbial ion‐trapping mechanisms, a mild and universal strategy is developed to construct highly porous amidoxime‐functionalized MOFs. DFT calculations and molecular force measurements reveal that the dual‐ligand amidoxime configuration significantly strengthens Ga(III) affinity.
Zhifang Lv   +9 more
wiley   +1 more source

Possible predicative role of electrical risk score on transcatheter aortic valve replacement outcomes in older patients. preliminary data [PDF]

open access: yes, 2018
Background:Transcatheter aortic valve replacement (TAVR) is an effective procedure capable to change the natural history of the degenerative aortic valve stenosis.
DI IORIO, Claudia   +9 more
core   +1 more source

Hereditary prolongation of QT interval. [PDF]

open access: yesHeart, 1972
Twocases, afather andson,withprolongation oftheQTinterval without coexistent deafness, aredescribed. Bothhada typical history, withsymptoms starting inchildhood, oftransient syncopal attacks, often triggered bystrong emotional orphysical stimuli, an abnormally prolonged QTinterval, bizarre T waves, andnormallaboratory values.
B W, Johansson, B, Jorming
openaire   +2 more sources

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

open access: yesAdvanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang   +7 more
wiley   +1 more source

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