Results 61 to 70 of about 1,444,780 (246)

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Prevalence and risk factors for prolonged QT interval and QT dispersion in patients with type 2 diabetes

, 2017
Produženi QT interval je udružen sa malignim srčanim aritmijama i naprasnom smrti...Prolonged QT interval is associated with malignant cardiac arrhythmias and sudden death..
Ninković, Vladan Ž.
core   +1 more source

Torsade de Pointes Triggered by Early Ventricular Escape Beats in a Patient with Complete Atrioventricular Block

Case Reports in Cardiology, 2016
Torsade de pointes is an uncommon and malignant form of polymorphic ventricular tachycardia and associated with a prolonged QT interval, which may be congenital or acquired.
Erkan Yildirim, Baris Bugan, Suat Gormel, Uygar Cagdas Yuksel, Murat Celik, Yalcin Gokoglan, Serdar Firtina, Sinan Iscen, Emre Yalcinkaya, Ugur Kucuk, Hasan Kutsi Kabul   +10 more
doaj   +1 more source

Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs

Journal of Pharmacological Sciences, 2012
Cloperastine is an antitussive drug, which can be received as an over-the-counter cold medicine. The chemical structure of cloperastine is quite similar to that of the antihistamine drug diphenhydramine, which is reported to inhibit hERG K+ channels and ...
Akira Takahara, Kaori Fujiwara, Atsushi Ohtsuki, Takayuki Oka, Iyuki Namekata, Hikaru Tanaka   +5 more
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Suppression of amiodarone‐induced torsade de pointes by landiolol in a patient with atrial fibrillation‐mediated cardiomyopathy

Annals of Noninvasive Electrocardiology, 2021
An elderly Japanese woman developed acute decompensated heart failure caused by persistent atrial fibrillation (AF) and left ventricular systolic dysfunction.
Koji Takahashi, Mina Yamashita, Tomoki Sakaue, Daijiro Enomoto, Shigeki Uemura, Takafumi Okura, Shuntaro Ikeda, Masafumi Takemoto, Yutaka Utsunomiya, Takashi Hyodo   +9 more
doaj   +1 more source

Prevalence and risk factors for prolonged QT interval and QT dispersion in patients with type 2 diabetes

, 2016
© 2016, The Author(s). Aims: Prolonged QT interval is associated with cardiac arrhythmias and sudden death. The present study determined the prevalence of prolonged QT interval and QT dispersion and defined their clinical and metabolic predictors in ...
Trenell M., Giga V., Ninkovic, Srdjan, Ninkovic V., Babic Marijana, Miloradović V., Stanojevic D., Jakovljević, Dragana, Lalić N., Dobric M., Seferovic P.   +10 more
core   +1 more source

MagGami: An Electromagnetic Origami Actuator With High Stiffness‐Switching Density for Lightweight Joint‐Space Wearable Haptics

Advanced Science, EarlyView.
Concept of the MagGami‐based joint‐space haptic glove. a) Comparison between Cartesian‐space fingertip force feedback and distributed joint‐space torque feedback, highlighting the limitations of representative motor‐driven, pneumatic, and smart material‐based haptic actuators.
Tianhao Jin, Zirui Niu, Qingyun Tang, Zemin Wang, Yu Qiao, Guocai Yao, Yong Zhou, Boxue Shan, Yan Zhang, Dangxiao Wang   +9 more
wiley   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source