Results 121 to 130 of about 201,462 (304)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Automatic Prominence Classification in Swedish

open access: yes, 2010
This study aims at automatically classifying levels of acoustic prominence on a dataset of 200 Swedish sentences of read speech by one male native speaker.
Ananthakrishnan, Gopal,   +2 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Prosodic prominence: a cue to distinguish young and old speakers?

open access: yes, 2015
, 2015Scholars highlight the structuring function of prosody in language production and comprehension processes ([1], [2], [3]). Prosody also gives information on referents' accessibility in the conversation ([4], [5], [6]).
Lacheret-Dujour, Anne   +2 more
core  

The dynamical process of a coronal transient associated with an eruptive prominence .1. Basic mechanism

open access: yes, 1983
The statistical correlation between an eruptive prominence and the coronal transient associated with this prominence implies that there should be a relationship between these two kinds of dynamical processes. This paper analyzes the dynamical effect of a
胡文瑞   +1 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

The timing of speech and gesture in two Niger-Congo languages: Implications for word-level prominence

open access: yesGlossa
Co-speech gestures are timed to occur with prosodically prominent syllables in several languages. In prior work in Indo-European languages, gestures are found to be attracted to stressed syllables, with gesture apexes preferentially aligning with ...
Hermann Keupdjio   +2 more
doaj   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Including Pitch Accent Optionality in Unit Selection Text-to-Speech Synthesis [PDF]

open access: yes, 2008
A significant variability in pitch accent placement is found when comparing the patterns of prosodic prominence realized by different English speakers reading the same sentences. In this paper we describe a simple approach to incorporate this variability
Clark, Robert A.J.   +2 more
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

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