Results 31 to 40 of about 145,461 (218)
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Multimodal prosody: gestures and speech in the perception of prominence in Spanish
Frontiers in CommunicationMultimodal communication cannot be properly understood without analyzing the natural interweaving of speech and gestures as it typically occurs in everyday spoken language, thus moving beyond studies that elicit gestures in the laboratory, most of which ...
Miguel Jiménez-Bravo +1 more
doaj +1 more source
Response to Fred Cummins: Looking for Rhythm in Speech
Empirical Musicology Review, 2012 This commentary briefly reviews three aspects of rhythm in speech. The first concerns the issues of what to measure and how measurements should relate to rhythm's communicative functions.
David House
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Lack of Syllable Duration as a Post-Lexical Acoustic Cue in Spanish in Contact with Maya
Languages, 2019 This paper focuses on the duration of stressed syllables in broad versus contrastive focus in Yucatecan Spanish and examines its connection with Spanish−Maya bilingualism. We examine the claim that phonemic vowel length in one language prevents the
Nuria Martínez García, Melanie Uth
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Cross-linguistic Evidence for Gender as a Prominence Feature
Frontiers in Psychology, 2015 This paper discusses recent findings in the online sentence processing research that suggest to consider gender information a prominence feature. Prominence features are hierarchically ordered information types that interact with formal features of ...
Yulia eEsaulova, Lisa eVon Stockhausen
doaj +1 more source