Results 61 to 70 of about 137,299 (256)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Prosodic focus in English vs. French: A scope account
Glossa, 2018 We compare the use of prosodic prominence in English and French to convey focus. While previous studies have found these languages, and Germanic vs. Romance more generally, to differ in their use of prominence to encode focus (e.g., Ladd 1990; 1996; 2008;
Heather Goad +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
An experimental investigation of the binding options of demonstrative pronouns in German
Glossa, 2018 This paper discusses data from two self-paced reading experiments as well as an acceptability rating study that shed light on the binding behaviour of demonstrative pronouns as opposed to personal pronouns.
Andreas Brocher, Stefan Hinterwimmer
doaj +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The interplay of prominence-lending factors and language production in children
Frontiers in Language SciencesSeveral factors influence how adult speakers produce an utterance and which element they choose to start with. For example, German-speaking adults are more likely to begin an utterance with an element if it is (a) in their focus of attention, (b) animate
Sarah Dolscheid, Martina Penke
doaj +1 more source
Acoustic classification of focus: On the web and in the lab
Laboratory Phonology, 2017 We present a new methodological approach which combines both naturally-occurring speech harvested on the web and speech data elicited in the laboratory.
Jonathan Howell +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Differential object marking in sign languages
Glossa, 2019 Sign languages are sometimes claimed to lack argument marking, yet they exhibit many devices to track and disambiguate referents. In this paper, I will argue that there are devices found across sign languages that demonstrate how object marking is a ...
Carl Börstell
doaj +2 more sources