Results 61 to 70 of about 201,462 (304)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

The Athletic Identity Measurement Scale-3rd Generation (AIMS-3G) Reliabilities and Factor Structures in Competing Athletes

open access: yesYouth
The AIMS-3G was developed to expand and reconceptualize previous measures and conceptualizations of athletic identity. Although the AIMS-3G has appeared in research, comprehensive tests of its validity and reliability had not extended beyond the initial ...
Marc Lochbaum   +4 more
doaj   +1 more source

El protagonismo de la mujer en el cuento “Petronella” de Jay Williams como recurso educativo

open access: yesRevista de Lenguas Modernas, 2017
Los estereotipos sexistas en la literatura infantil reiteran patrones sociales y utilizan medios como la escuela y la familia para su transmisión. Este artículo analiza el papel de la mujer, sus profesiones, valores y objetos atribuidos en los cuentos ...
María Dolores Corpas Arellano
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Automatic Prominence Annotation of a German Speech Synthesis Corpus: Towards Prominence-Based Prosody Generation for Unit Selection Synthesis

open access: yes, 2010
Windmann A, Wagner P, Tamburini F, Arnold D, Oertel C. Automatic Prominence Annotation of a German Speech Synthesis Corpus: Towards Prominence-Based Prosody Generation for Unit Selection Synthesis.
Wagner, Petra ; https://orcid.org/   +4 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

On Automatic Prominence Detection for German

open access: yes, 2007
Tamburini F, Wagner P. On Automatic Prominence Detection for German. In: Proceedings of Interspeech 2007. 2007: 1809-1812.Perceptual prominence is an important indicator of a word's and syllable's lexical, syntactic, semantic and pragmatic status in a ...
Wagner, Petra ; https://orcid.org/   +4 more
core  

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