Results 141 to 150 of about 795,608 (343)
BioTechniques, 2008 System-oriented applications of genetic engineering, such as metabolic engineering, often require the serial optimization of enzymatic reaction steps, which can be achieved by transcriptional fine-tuning.
Stephan Braatsch +4 more
doaj +1 more source
Functional analysis of CcDREB1D promoter region from two genotypes of Coffea canephora through genetic transformation of Nicotiana tabacum : S03P08 [PDF]
, 2013 Although some studies in plant physiology resulted in a better understanding of the mechanisms involved in drought tolerance in coffee, knowledge about the metabolic and molecular changes involved in the response of the coffee plant to water deficit ...
Alves, Gabriel Sergio Costa +4 more
core
International Journal of Neuropsychopharmacology, 2012 P11 (S100A10) has been associated with the pathophysiology of depression both in human and rodent models. Different types of antidepressants have been shown to increase P11 levels in distinct brain regions and P11 gene therapy was recently proven ...
P. A. Melas +10 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley +1 more source
Spt6 is required for the fidelity of promoter selection
bioRxiv, 2018 Spt6 is a conserved factor that controls transcription and chromatin structure across the genome. Although Spt6 is viewed as an elongation factor, spt6 mutations in Saccharomyces cerevisiae allow elevated levels of transcripts from within coding regions,
Stephen M. Doris +7 more
semanticscholar +1 more source
Animal Biotechnology, 2012 Average daily gain (ADG) and feed efficiency (FE) are important factors for assessing productivity in farm animals. Myostatin (MSTN), previously called GDF8, is a member of transforming growth factor β (TGFβ) superfamily. It is a negative regulator for both embryonic development and adult homeostasis of skeletal muscle.
Jen-Wen Shiau +5 more
openaire +3 more sources
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Patterns of DNMT1 Promoter Methylation in Patients with Acute Lymphoblastic Leukemia
International Journal of Hematology-Oncology and Stem Cell Research, 2016 Background: Acute lymphoblastic leukemia (ALL) is a clonal malignant disorder characterized by an uncontrolled proliferation of immature T or B lymphocytes.
Tirdad Rahmani +5 more
doaj
Genetic Basis of Persister Tolerance to Aminoglycosides in Escherichia coli
mBio, 2015 Persisters are dormant variants that form a subpopulation of drug-tolerant cells largely responsible for the recalcitrance of chronic infections. However, our understanding of the genetic basis of antibiotic tolerance remains incomplete.
Yue Shan +4 more
semanticscholar +1 more source
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, EarlyView.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source