Results 241 to 250 of about 390,492 (308)

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

An Integrative ATAC-Seq and RNA-Seq Analysis of Spleen Tissues from Largemouth Bass (<i>Micropterus salmoides</i>) Infected with Iridovirus (LMBV). [PDF]

Int J Mol Sci
Sun H, Hua J, Tao Y, Lu S, Wang W, Dong Y, Zhang L, He J, He J, Qiang J.   +9 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Brain Cancer: Molecular Alterations and Emerging Trends in Neuropharmacology. [PDF]

Int J Mol Sci
Leskova B, D'Agostino I, Mattova S, Urbanska N, Blicharova A, Simko P, Toplu A, Karaman M, Kiskova-Simkova T.   +8 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A system for transferring large genetic loci in <i>Bacteroides</i> enables hemicellulose utilization in <i>Bacteroides thetaiotaomicron</i> and characterization of a locus from an uncultivated strain. [PDF]

Appl Environ Microbiol
Porter NT, Kmezik C, Lee Y-H, Siewers V, Pope PB, Koropatkin N, Martens E, Larsbrink J.   +7 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

So Fragile, So Human: Noncoding DNA Regions Orchestrating Gene Expression Involved in Neurodevelopmental Disorders and in Human Brain Evolution. [PDF]

Int J Mol Sci
Marenco C, Pozzolini G, Casciaro M, Morales M, Barone C, Morciano D, Barillari C, Zakirova E, Antoniazzi G, Lahoud T, Mosconi F, Cabassi D, Noonan JP, Bacchelli E, Nicolis SK.   +14 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Duplicate, diversify, repeat: The evolution of NOTCH2NL. [PDF]

Cell Genom
Egyes N, Gokhman D.
europepmc   +1 more source