Results 51 to 60 of about 924,951 (335)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Prediction of Prokaryotic and Eukaryotic Promoters Using Convolutional Deep Learning Neural Networks [PDF]
arXiv, 2016 Accurate computational identification of promoters remains a challenge as these key DNA regulatory regions have variable structures composed of functional motifs that provide gene specific initiation of transcription. In this paper we utilize Convolutional Neural Networks (CNN) to analyze sequence characteristics of prokaryotic and eukaryotic promoters
arxiv
Dynamical Analysis on Gene Activity in the Presence of Repressors and an Interfering Promoter [PDF]
, 2008 Transcription is regulated through interplay between transcription factors, an RNA polymerase(RNAP), and a promoter. Even for a simple repressive transcription factor that disturbs promoter activity at the initial binding of RNAP, its repression level is not determined solely by the dissociation constant of transcription factor but is sensitive to the ...
arxiv +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Promotion on Generalized Oscillating Tableaux and Web Rotation [PDF]
arXiv, 2017 We introduce the notion of a generalized oscillating tableau and define a promotion operation on such tableaux that generalizes the classical promotion operation on standard Young tableaux. As our main application, we show that this promotion corresponds to rotation of the irreducible $A_2$-webs of G. Kuperberg.
arxiv
Model of Transcriptional Activation by MarA in Escherichia coli [PDF]
, 2009 We have developed a mathematical model of transcriptional activation by MarA in Escherichia coli, and used the model to analyze measurements of MarA-dependent activity of the marRAB, sodA, and micF promoters in mar-rob- cells. The model rationalizes an unexpected poor correlation between the mid-point of in vivo promoter activity profiles and in vitro ...
arxiv +1 more source
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
Marketing potential of the e-sports market in Serbia [PDF]
Ekonomski SignaliThe fast-growing e-sports market opens up numerous marketing opportunities that are primarily reflected in its promotional capacities. The main prerequisite for appropriate positioning through promotion is knowing the characteristics of the target groups
Ratković Milijanka C., Pećić Milutin
doaj +1 more source
E-Commerce Promotions Personalization via Online Multiple-Choice Knapsack with Uplift Modeling [PDF]
arXiv, 2021 Promotions and discounts are essential components of modern e-commerce platforms, where they are often used to incentivize customers towards purchase completion. Promotions also affect revenue and may incur a monetary loss that is often limited by a dedicated promotional budget. We study the Online Constrained Multiple-Choice Promotions Personalization
arxiv
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source