Results 71 to 80 of about 893,728 (266)
Dynamic modulation of enhancer‐promoter and promoter‐promoter connectivity in gene regulation
BioEssaysAbstractEnhancers are short segments of regulatory DNA that control when and in which cell‐type genes should be turned on in response to a variety of extrinsic and intrinsic signals. At the molecular level, enhancers serve as a genomic scaffold that recruits sequence‐specific transcription factors and co‐activators to facilitate transcription from ...
Shiho Makino, Takashi Fukaya
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
JPHEInstitutions of higher education desire their faculty members to be high-quality researchers while also acting as engaged academic citizens who produce public scholarship.
Zach Taylor +2 more
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Deusto Journal of Human Rights, 2017 With the end of the Cold War, one of the most important developments has clearly been the recognition of the universal value of human rights and of the need to effectively respect and promote them at all levels of international relations.
Daniela Santos Nascimento
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Journal of Thoracic and Cardiovascular Surgery, 2001 Promotion is an active process. At the beginning of his or her academic career, the surgeon should begin planning for this process. Surgeons need to understand the promotion documents at their institutions and to have a timetable for achieving tenure at the appropriate time.
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Управление культуройTaking into account the increased interest in social networks, confirmed by VTsIOM data for 2023 (86% of surveyed Russians who use social networks spend time on them almost every day), the article examines the communities of music and art educational ...
Elizaveta K. Plekhanova
doaj