Results 121 to 130 of about 1,398,017 (305)

Evaluation and promotion strategy of resilience of urban water supply system under flood and drought disasters. [PDF]

Sci Rep, 2022
Li Z, Zhao H, Liu J, Zhang J, Zhang J, Shao Z.   +5 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Machine learning based personalized promotion strategy of piglets weaned per sow per year in large-scale pig farms. [PDF]

Porcine Health Manag, 2022
Zhou X, Guan R, Cai H, Wang P, Yang Y, Wang X, Li X, Song H.   +7 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Improving effectiveness of the project activity of charitable foundations

Вестник университета
The article discusses improvement of the effectiveness of the project activities of charitable foundations. The authors analyse various approaches to charity and charitable activities and reveal stages of preparation and implementation of sponsorship ...
E. A. Sokolova, P. V. Zozulya
doaj   +1 more source

EXPORT-PROMOTING TRADE STRATEGY

The World Bank Research Observer, 1988
This article outlines issues with and evidence for supporting export-promoting trade strategy.
openaire   +2 more sources

Executive Summary: Evaluation of the MacArthur Foundation's Human Rights and International Justice Grantmaking in Nigeria 2000-2012 [PDF]

, 2014
The MacArthur Foundation commissioned Itad to conduct an evaluation of the Foundation's Human Rights and International Justice (HRIJ) grant?making program in Nigeria between 2000 and 2012.
Abdulkareem Lawal, Abigail Hansen, Anna Paterson, Emily Richardson, Julian Barr, Olly Owen, Pierre Robert   +6 more
core  

Walking Psychotherapy As a Health Promotion Strategy to Improve Mental and Physical Health for Patients and Therapists: Clinical Open-Label Feasibility Trial. [PDF]

Can J Psychiatry, 2022
Koziel N, Vigod S, Price J, Leung J, Hensel J.   +4 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source