Results 221 to 230 of about 1,394,259 (304)

Policies and strategies on active and healthy ageing: a scoping review of the recommendations of European and international agencies. [PDF]

Front Public Health
Caristia S, Viola E, Kalemi T, Servetti D, Poy S, Faggiano F.   +5 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Preemptive Mpox Vaccine Deployment: Aligning Strategy With Reality. [PDF]

J Infect Dis
Jung SM, Miura F, Murayama H, Funk S, Wallinga J, Lessler J, Endo A.   +6 more
europepmc   +1 more source

Dissemination and promotion strategy

This report is an output of Task 51 presenting the dissemination objectives target groups measures and activities monitoring and ...
openaire   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Global policy approaches to combat early childhood caries: a scoping review with evidence map. [PDF]

Front Oral Health
Lydia N, Imran M, Atique S, Bahammam HA, Moothedath M, Habibullah MA, Kolarkodi SH.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Reactive oxygen species promotion drives auranofin's antiviral activity against hepatitis E virus. [PDF]

J Virol
Tiller K, Williams ST, Wang B, Tian D, Meng X-J, Weger-Lucarelli J.   +5 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Rectifying misconceptions and misimplementations: A critical examination of health literacy interventions in health systems. [PDF]

Health Promot Perspect
Allahverdipour H.
europepmc   +1 more source