Results 181 to 190 of about 4,804,928 (276)

Prompt engineering in medical education. Dissecting the new technological frontier in Digestive Surgery. [PDF]

Arq Bras Cir Dig
Gama Filho OP, Lima Ribeiro BD, Kassab P.   +2 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Ontology-driven generation of parameters for health technology assessment models: a prompt engineering study. [PDF]

Int J Technol Assess Health Care
González-González E, Castilla-Rodríguez I, Dorta-Hernández JA.   +2 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Biomedical Large Language Models and Prompt Engineering for Causality Assessment of Individual Case Safety Reports in Pharmacovigilance. [PDF]

Pharm Res
Heckmann NS, Papoutsi DG, Barbieri MA, Battini V, Mølgaard SN, Schmidt SØ, Melskens L, Sessa M.   +7 more
europepmc   +1 more source

Beyond Prompt Engineering

Based on a Zenodo-published formal paper introducing FRFP, a mathematical protocol architecture for long-horizon human–AI collaboration and governance.  FRFP Proved/derived protocol-level results around explicit vs tacit separation, safe-horizon limits, and why fully automated “correctness guarantees” break down in long runs. Beyond Prompt Engineering,
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Impact of Specific Prompt Engineering Techniques on the Readability of LLM-Generated Patient Materials in Gastroenterology and Hepatology. [PDF]

Dig Dis Sci
Ramji HF, Gatiganti A, Janwadkar A, Lampenfeld J, Simeone IM, Atkuru A, Mathias J, Mrowczynski S, Poonja S, Gilliard C, Lewis S, Arumugam P, Freedman C, Morales L, Martin E, Zhou L, Zalomek C, Dixit D, Abdulsada S, Houle M, Alias M, Delk M, Glover SC, Ting PS.   +23 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Benchmarking Large Language Models and Prompt Engineering Strategies in Microsatellite Instability Cancers: Evaluation Study. [PDF]

J Med Internet Res
Zhang Y, Song J, Bi C, Zheng X, Xu Z, Cao D, Shen B.   +6 more
europepmc   +1 more source