Results 121 to 130 of about 83,605 (232)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Interview questions and prompts.
, 2016 Interview questions and prompts.
Prasad S. Nishtala (2575777) +3 more
core +1 more source
Profile: Issues in Teachers' Professional Development, 2008 Motivated by the conviction that valid and reliable assessments can foster positive changes in instruction, we implemented a writing assessment system in the adult English program at the Language Center, EAFIT University, Medellín. To evaluate the impact
Ana Patricia Muñoz, Martha E Álvarez
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Can Large Language Models Truly Understand Prompts? A Case Study with Negated Prompts
, 2022 Previous work has shown that there exists a scaling law between the size of Language Models (LMs) and their zero-shot performance on different downstream NLP tasks.
Seo, Minjoon, Jang, Joel, Ye, Seonghyeon
core
Revista Catalana de PedagogiaL’experiència que presentem exemplifica l’aplicació pràctica de diversos prompts en ChatGPT 3.5 dissenyats per dur a terme els procediments associats a l’anàlisi qualitativa d’informes i blogs de l’Organització de les Nacions Unides per a l’Educació ...
María Paz Sandín Esteban +1 more
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Limits of Metacognitive Prompts for Confidence Judgments in an Interactive Learning Environment
Open Education StudiesMetacognitive activities are reported to improve learning but prompts to support metacognition have only been investigated with mixed results. In the present study, metacognitive prompts for confidence judgments were implemented in a learning platform to
Klar Maria +2 more
doaj +1 more source