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Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Proof of concept - Community Land Trusts [PDF]
This ‘proof of concept’ report seeks to examine and quantify the progress made by Community Land Trusts (CLTs) now that there are a significant number of homes on the ground.
Dayson, KT, Paterson, R
core
Design and proof of concept for silicon-based quantum dot quantum bits [PDF]
Spins based in silicon provide one of the most promising architectures for quantum computing. Quantum dots are an inherently scalable technology. Here, we combine these two concepts into a workable design for a silicon-germanium quantum bit.
Eriksson, Mark A. +6 more
core +2 more sources
Age‐related male hypogonadism is often associated with obesity‐related metabolic disorders and impaired regulation of the testicular anti‐inflammatory microenvironment.
Zhendong Zhu +10 more
doaj +1 more source
With the advent of 6G technology, the proliferation of interconnected devices necessitates a robust, fully connected intelligence network. Federated Learning (FL) stands as a key distributed learning technique, showing promise in recent advancements ...
Lorenzo Ridolfi +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Improving dialysis adherence for high risk patients using automated messaging: Proof of concept [PDF]
Comorbidities and socioeconomic barriers often limit patient adherence and self-management with hemodialysis. Missed sessions, often associated with communication barriers, can result in emergency dialysis and avoidable hospitalizations.
An, T. +6 more
core +2 more sources
Myologists working in Padua (Italy) were able to continue a half-century tradition of studies of skeletal muscles, that started with a research on fever, specifically if and how skeletal muscle contribute to it by burning bacterial toxin.
Ugo Carraro
doaj +1 more source
Augmented reality-guided periacetabular osteotomy—proof of concept
Background The Ganz’ periacetabular osteotomy (PAO) consists of four technically challenging osteotomies (OT), namely, supraacetabular (saOT), pubic (pOT), ischial (iOT), and retroacetabular OT (raOT).
Pascal Kiarostami +7 more
doaj +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source

