Results 51 to 60 of about 678,617 (289)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Proof-of-Concept Experiments for Quantum Physics in Space

, 2003
Quantum physics experiments in space using entangled photons and satellites are within reach of current technology. We propose a series of fundamental quantum physics experiments that make advantageous use of the space infrastructure with specific ...
Aspelmeyer, Markus, Brukner, Caslav, Jennewein, Thomas, Kaltenbaek, Rainer, Leeb, Walter R., Pfennigbauer, Martin, Zeilinger, Anton   +6 more
core   +1 more source

The Versatile Transceiver Proof of Concept [PDF]

, 2009
SLHC experiment upgrades will make substantial use of optical links to enable high-speed data readout and control. The Versatile Link project will develop and assess optical link architectures and components suitable for deployment at SLHC.
Detraz, S, Papadopoulos, S, Papakonstantinou, I, Rui Silva, S, Seif el Nasr, S, Sigaud, C, Soos, C, Stejskal,, Troska, J, Vasey, F   +9 more
core   +1 more source

Harm effects in non-registered versus registered randomized controlled trials of medications: a retrospective cohort study of clinical trials

BMC Medicine
Background Trial registration aims to address potential bias from selective or non-reporting of findings, and therefore has a vital role in promoting transparency and accountability of clinical research. In this study, we aim to investigate the influence
Chang Xu, Shiqi Fan, Luis Furuya-Kanamori, Sheyu Li, Lifeng Lin, Haitao Chu, Su Golder, Yoon Loke, Sunita Vohra   +8 more
doaj   +1 more source

From proof-of-concept to exploitable

Cybersecurity, 2019
Exploitability assessment of vulnerabilities is important for both defenders and attackers. The ultimate way to assess the exploitability is crafting a working exploit. However, it usually takes tremendous hours and significant manual efforts. To address
Yan Wang, Wei Wu, Chao Zhang, Xinyu Xing, Xiaorui Gong, Wei Zou   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Satellite Power System total proof of concept program [PDF]

, 1980
Requirements for a solar power satellite (SPS) orbital demonstration for providing a system proof of concept within the decade of the 1980s are outlined.
Mcrae, W. V., Jr.
core   +1 more source

Influence of lack of blinding on the estimation of medication-related harms: a retrospective cohort study of randomized controlled trials

BMC Medicine
Background Empirical evidence suggests that lack of blinding may be associated with biased estimates of treatment benefit in randomized controlled trials, but the influence on medication-related harms is not well-recognized.
Chang Xu, Fengying Zhang, Suhail A. R. Doi, Luis Furuya-Kanamori, Lifeng Lin, Haitao Chu, Xi Yang, Sheyu Li, Liliane Zorzela, Su Golder, Yoon Loke, Sunita Vohra   +11 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Active control of space structures: Proof of concept experiment [PDF]

, 1982
Modern control theory easily works with multiple input/multiple output systems. Two types of systems which fall into this category are flexible systems, where many measurements and several actuators are necessary to provide control over bending behavior,
Breakwell, J. A.
core   +1 more source