Results 61 to 70 of about 678,617 (289)

Not Just a Theory—The Utility of Mathematical Models in Evolutionary Biology [PDF]

, 2014
Models have made numerous contributions to evolutionary biology, but misunderstandings persist regarding their purpose. By formally testing the logic of verbal hypotheses, proof-of-concept models clarify thinking, uncover hidden assumptions, and spur new
Brandvain, Y., Dhole, S., Fitzpatrick, C., Goldberg, E., Servedio, M., Stern, C., Van Cleve, J., Yeh, J.   +7 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation

BMC Medicine
Background While medications are essential for preventing and treating disease, they can also cause harm. Evidence synthesis has been widely adopted for evaluating harms, but traditional methods are resource-intensive and may constrain timely decision ...
Chang Xu, Suhail A. Doi, Sunita Vohra, Luis Furuya-Kanamori, Yingxia Wang, Lijun Tang, Yuan Tian, Shiqi Fan, Zhen Peng, Evan Mayo-Wilson, Lifeng Lin, Haitao Chu, M. Hassan Murad, Tianqi Yu, Sheyu Li, Yaolong Chen, Su Golder, Yoon Loke, Justin Clark, Paul Glasziou, Liang Du, Houwen Lin, Zhichun Gu, PROMISE Collaborative Research Network   +23 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Off-label use of clomiphene citrate to treat anabolic androgenic steroid induced hypogonadism upon cessation among men (CloTASH) – A pilot study protocol

MethodsX
Background: Non-prescribed anabolic androgenic steroid (AAS) use is associated with AAS-induced hypogonadism (ASIH), and metabolic, cardiovascular, and mental health risks.
Ingrid Amalia Havnes, Hans Christian Bordado Henriksen, Per Wiik Johansen, Astrid Bjørnebekk, Sudan Prasad Neupane, Jonny Hisdal, Ingebjørg Seljeflot, Christine Wisløff, Marie Lindvik Jørstad, Jim McVeigh, Anders Palmstrøm Jørgensen   +10 more
doaj   +1 more source

Ranking Power Spectra: A Proof of Concept

Entropy, 2019
To characterize the irregularity of the spectrum of a signal, spectral entropy and its variants are widely adopted measures. However, spectral entropy is invariant under the permutation of the power spectrum estimations on a predefined grid.
Xilin Yu, Zhenning Mei, Chen Chen, Wei Chen   +3 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Pythia version 7-0.0 - a proof-of-concept version [PDF]

, 2000
This document describes the first proof-of-concept version of the Pythia7 program. Pythia7 is a complete re-write of the Pythia program in C++. It is mainly intended to be a replacement for the `Lund' family of event generators, but is also a toolkit ...
Andersson, Andersson, Booch, Brown, Caso, Edén, Kuhn, Leif Lönnblad, Lönnblad, Lönnblad, Lönnblad, Lönnblad, Marc Bertini, Marchesini, Pfeiffer, Shiers, Sjöstrand, Sjöstrand, Sjöstrand, Torbjörn Sjöstrand   +19 more
core   +3 more sources

Forward and Inverse Robotics Kinematics JavaScript-HTML5 Simulator

Proceedings
The development of technology nowadays, and specifically in the field of robotics, is an increasingly developed field of research and development by the scientific community to optimize its productivity [...]
Spyridon Mitropoulos, Odysseas Tsakiridis, Ioannis Christakis   +2 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source