Results 121 to 130 of about 1,573,175 (303)
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source
Coalition-proof supply function equilibria under capacity constraints [PDF]
Whereas in the absence of capacity constraints the Cournot outcome is the unique coalition-proof supply function equilibrium outcome, the presence of capacity constraints may enlarge the set of equilibrium outcomes.
Delgado, Juan
core +1 more source
Proof-theoretic analysis of termination proofs
\textit{E. A. Cichoń} [in: Proof theory, Int. Summer School and Conf., Leeds, UK, 1990, 173-193 (1992; Zbl 0793.03057)] raised the question whether there is a relation between the order type of a termination ordering \(\prec\) and the lengths of reduction sequences in a rewrite system reducing under \(\prec\). \textit{D. Hofbauer} [Theor. Comput.
openaire +2 more sources
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto +12 more
wiley +1 more source
In this paper we report on our analysis of textbooks commonly used for teaching students about proof in geometry in lower secondary school in Japan. From our analysis we found that, as expected from the curriculum specification, deductive reasoning is ...
Kunimune, Susumu +2 more
core +1 more source
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem +9 more
wiley +1 more source
Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR
ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the treatment effect of anticoagulation versus antiplatelet therapy in patients ...
Elena Badillo Goicoechea +53 more
wiley +1 more source
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
Proof-of-Principle of Molecular-Scale Arithmetic
Proof-of-Principle of Molecular-Scale ...
A. Prasanna de Silva (1630753) +1 more
core +1 more source
Automated Hand Flexor Tendon–Thickness Measurement in Systemic Sclerosis
Objective Systemic sclerosis (SSc) can affect flexor tendons, contributing to hand function problems and reduced quality of life. Tendon changes are currently assessed with ultrasonography and measured manually, a time‐consuming process prone to interobserver variability.
Mark Greveling +4 more
wiley +1 more source

