Results 51 to 60 of about 1,573,175 (303)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A Communication Proof Equilibrium Concept [PDF]
, 1990 This paper proposes an equilibrium concept for the classes of environments in which players can cornmunicate with each other but cannot rnake binding agreernents. This Cornmunication-proof equilibrium is intended to be regarded as an extension of both
Ferreira, José Luis
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Developing Students Ability To Write Mathematical Proof By Polya Method [PDF]
, 2011 Both writing and reading a proof is equally not easy. Some mathematicians attested that students found difficulties in mathematical proving. Mathematics and mathematics education experts like Jones (1997, 2001), Weber (2001), and Smith (2006) found that ...
Kodirun, Kodirun
core
Proof in dynamic geometry contexts
, 1998 Proof lies at the heart of mathematics yet we know from research in mathematics education that proof is an elusive concept for many mathematics students.
Hoyles, Celia, Jones, Keith
core +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
The Faithfulness of Fat: A Proof-Theoretic Proof [PDF]
Studia Logica, 2015 It is known that there is a sound and faithful translation of the full intuitionistic propositional calculus into the atomic polymorphic system Fat, a predicative calculus with only two connectives: the conditional and the second-order universal quantifier.
Fernando Ferreira 0001, Gilda Ferreira
openaire +2 more sources
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source