Results 71 to 80 of about 156,901 (262)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Towards Uniform Certification in QBF [PDF]

Logical Methods in Computer Science
We pioneer a new technique that allows us to prove a multitude of previously open simulations in QBF proof complexity. In particular, we show that extended QBF Frege p-simulates clausal proof systems such as IR-Calculus, IRM-Calculus, Long-Distance Q ...
Leroy Chew, Friedrich Slivovsky
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Data-driven multinomial random forest: a new random forest variant with strong consistency

Journal of Big Data
In this paper, we modify the proof methods of some previously weakly consistent variants of random forest into strongly consistent proof methods, and improve the data utilization of these variants in order to obtain better theoretical properties and ...
JunHao Chen, XueLi Wang, Fei Lei
doaj   +1 more source

GOST 34.11-2018 Analysis in The Context of Zero-Knowledge Proofs

Безопасность информационных технологий
Zero-knowledge proofs are being increasingly applied to a wide range of tasks in modern distributed information systems. Of particular interest are such areas of activity as digital asset management systems, anonymous electronic voting systems, and ...
Vladlen D. Afonin, Sergey V. Zapechnikov, Igor A. Prostov   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

On the complexity of cutting-plane proofs

Discrete Applied Mathematics, 1987
As introduced by \textit{V. Chvatal} [Discrete Math. 4, 305-337 (1973; Zbl 0253.05131)] cutting planes provide a canonical way of proving that every integral solution of a given system of linear inequalities satisfies another specified inequality. In this note we make several observations on the complexity of such proofs in general and when restricted ...
William J. Cook, Collette R. Coullard, György Turán   +2 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source