Results 191 to 200 of about 324,270 (304)

Clinical proof of concept for small molecule mediated inhibition of IL-17 in psoriasis. [PDF]

PLoS One
Warren RB, Hunter HJA, Papp KA, Gordon KB, Tang MT, Enejosa JV, Huang KC, Raha D, Batugedara HM, Skinner C, Kobel PA, Rademacher PM, Ghilardi N, Fatheree P, Jacobsen JR, Lu TT.   +15 more
europepmc   +1 more source

Enhancing and Stabilizing Hydrogen Catalysis Through [NiFe]‐Hydrogenase Immobilization Within Macroporous Covalent Organic Frameworks

Advanced Functional Materials, EarlyView.
[NiFe]‐hydrogenases efficiently catalyze hydrogen conversion, but their instability limits biotechnological applications. Here it is shown that encapsulating hydrogenase into hierarchical COFs with macro‐ and micropores and functionalized with sulfonic or carboxylic acid groups improves enzyme stability and electron transfer to electrodes.
Islam E. Khalil, Armel F. Tadjoung Waffo, Prasenjit Das, Sagie Katz, Sandra Kunow, Christian Lorent, Yasmine Ziouani, Warisha Tahir, Augustine A. Owusu, Oliver Lenz, Ingo Zebger, Stefan Frielingsdorf, Arne Thomas   +12 more
wiley   +1 more source

Outcomes of an Intravenous to Subcutaneous Infliximab (CT-P13) Strategy in Takayasu Arteritis: A Proof-of-Concept Prospective Study. [PDF]

ACR Open Rheumatol
Iorio L, Davanzo F, Fiorin E, Codirenzi M, Prevedello R, Doria A, Padoan R.   +6 more
europepmc   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Regulatory Interactions and Learnings-RADIAL the Trials@Home Proof-of-Concept Trial on Decentralization. [PDF]

Clin Pharmacol Ther
Gardarsdottir H, Traore H, Huntley K, Mistry D, de Jong AJ, Legathe A, de Smedt T, Askin S, Heath M, Corriol-Rohou S, Lagerwaard B, Zuidgeest MGP, IMI Trials@Home Consortium.   +12 more
europepmc   +1 more source

Fully Bio‐Based Gelatin Organohydrogels via Enzymatic Crosslinking for Sustainable Soft Strain and Temperature Sensing

Advanced Functional Materials, EarlyView.
Enzymatically crosslinked gelatin‐based organohydrogels, fabricated through a fully bio‐based and scalable process, exhibit exceptional strain and temperature sensing capabilities with minimal interference from environmental humidity. These transparent, stretchable, and ionically conductive materials operate without synthetic fillers or dopants.
Pietro Tordi, Adrián Tamayo, Yeonsu Jeong, Bin Han, Tamer Al Kayal, Aida Cavallo, Massimo Bonini, Paolo Samorì   +7 more
wiley   +1 more source

How LLMs can advance safety case intake-points to consider and insights from a proof of concept. [PDF]

Ther Adv Drug Saf
Roemming HJ, Hauben M, Wannhoff W, Schaffer C, Tihaa I, Heitmann M, Mengling V.   +6 more
europepmc   +1 more source

Alkali Ion‐Incorporated HfO2 Dielectrics for Reconfigurable Neuromorphic Computing

Advanced Functional Materials, EarlyView.
This work presents an indium gallium zinc oxide (IGZO) transistor with an alkali cation‐integrated hafnium dioxide (HfO2) dielectric exhibiting synaptic behavior via ion retention. The solution‐based film fabrication strategy overcomes the limitations of atomic layer deposition (ALD) and precursor coating, enabling the control of synaptic retention ...
Seung Yeon Ki, In Cheol Kwak, Seonkwon Kim, Jihyun Kim, Dong Gue Roe, Se‐Jin Kim, Joohoon Kang, Jeong Ho Cho   +7 more
wiley   +1 more source

Repurposing space medical technology for perioperative and intensive care: a clinical proof-of-concept. [PDF]

Br J Anaesth
Scarpa J, Blattman N, Leibowitz H, Sobol I, Zhang Q, Strangman G.   +5 more
europepmc   +1 more source

Robust and Reversible Thermofluorescence in Solvent‐Free Thermoplastic Polyurethane Composites

Advanced Functional Materials, EarlyView.
Thermofluorescent polymer composites with high‐contrast optical outputs are prepared by solvent‐free blending of indenoquinacridone dye into a thermoplastic polyurethane matrix. The temperature‐dependent fluorescence originates from aggregation–dissociation of the dye molecules, regulated by competing hydrogen bonds from the polymer matrix.
Guanghua Yu, Bowen Tian, Jazmine Aiya Marquez, Chia‐Min Hsieh, Qingsheng Wang, Hung‐Jue Sue, Mohammed Al‐Hashimi, Peiran Wei, Lei Fang   +8 more
wiley   +1 more source