Results 221 to 230 of about 1,774,744 (290)

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

Improving sleep in ICUs through real-time sleep monitoring: a proof-of-concept study. [PDF]

Ann Intensive Care
Drouot X, Heraud Q, Melone MA, Ragot S, Frat JP, Coudroy R, Boissier F, Veinstein A, Chatellier D, Arrivé F, Le Pape S, Marchasson L, Rault C, Thille AW.   +13 more
europepmc   +1 more source

High‐Throughput Generation of Tumor Spheroids via Droplet Microfluidics for siRNA‐Loaded Nanomedicine Assessment

Advanced Healthcare Materials, EarlyView.
A droplet microfluidic platform is employed to enable high‐throughput, uniform tumor spheroid generation for evaluating siRNA‐loaded nanomedicines at the protein level. As a proof of concept, breast (MCF‐7) and brain (U87 MG) cancer cell lines are investigated using this platform, revealing penetration profiles and therapeutic responses between the two
Ling Liu, Guoying Wang, Yang Zhang, Bingyang Shi, Ming Li   +4 more
wiley   +1 more source

Apple-Derived Vesicles Orchestrate Bone Regeneration: <i>In Vitro</i> Proof of Concept. [PDF]

Int J Mol Sci
Brunello G, Vitali I, Ardondi L, Cavaleri MP, Sileo L, Degasperi M, Zalunardo F, Becker K, Schwarz-Herzke B, Sivolella S, Lovatti L, Ferroni L, Zavan B.   +12 more
europepmc   +1 more source

Laser‐Assisted Processing and Modification of Bioactive Glasses: A Review

Advanced Healthcare Materials, EarlyView.
Laser technologies provide powerful tools to process and transform bioactive glasses for advanced biomedical applications. This review discusses laser‐matter interaction mechanisms, laser surface engineering, and laser‐assisted fabrication of scaffolds and nanofibers.
Antonio Riveiro, Mario González‐Quintas, Mónica Fernández‐Arias, Jesús del Val, Félix Quintero, Rafael Comesaña, Fernando Lusquiños, Julian R. Jones, Juan Pou   +8 more
wiley   +1 more source

Creating Engineered NAC Flaps Using in Vivo Revascularization: A Proof-Of-Concept Study. [PDF]

Stem Cell Rev Rep
Berkane Y, Abaci A, Ellis BW, van Dieren L, Hendi E, Oubari H, Bertheuil N, Oganesyan R, Cetrulo CL, McCarthy ME, Randolph MA, Lellouch AG, Uygun BE.   +12 more
europepmc   +1 more source

Proof-of-Concept (1)

This reports and provides the proof-of-concept software. It shall include also data methodology aspects, and a section dedicated to each of the demos that integrate the proof-of-concept. The proof-of-concept shall be first described on M24, already with an envisioned set of first demos. Then, in M34, the full aspects concerning the proof-of-concept and
openaire   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Roadmap for the accelerated development and clinical translation of fluorescent tracers: Adalimumab-680LT as a proof of concept. [PDF]

Int J Pharm X
Huizinga HK, van Dijken RJ, Gareb B, Dekkers BGJ, van Zanten J, Westra HH, Koopmans P, Nagengast WB, Lub-de Hooge MN.   +8 more
europepmc   +1 more source