Results 41 to 50 of about 324,270 (304)

Influence of lack of blinding on the estimation of medication-related harms: a retrospective cohort study of randomized controlled trials

BMC Medicine
Background Empirical evidence suggests that lack of blinding may be associated with biased estimates of treatment benefit in randomized controlled trials, but the influence on medication-related harms is not well-recognized.
Chang Xu, Fengying Zhang, Suhail A. R. Doi, Luis Furuya-Kanamori, Lifeng Lin, Haitao Chu, Xi Yang, Sheyu Li, Liliane Zorzela, Su Golder, Yoon Loke, Sunita Vohra   +11 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A Substrate-Independent Benthic Sampler (SIBS) for Hard and Mixed-Bottom Marine Habitats: A Proof-of-Concept Study [PDF]

, 2021
Nigel Keeley, Olivier Laroche, Murray Birch, Xavier Pochon   +3 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Off-label use of clomiphene citrate to treat anabolic androgenic steroid induced hypogonadism upon cessation among men (CloTASH) – A pilot study protocol

MethodsX
Background: Non-prescribed anabolic androgenic steroid (AAS) use is associated with AAS-induced hypogonadism (ASIH), and metabolic, cardiovascular, and mental health risks.
Ingrid Amalia Havnes, Hans Christian Bordado Henriksen, Per Wiik Johansen, Astrid Bjørnebekk, Sudan Prasad Neupane, Jonny Hisdal, Ingebjørg Seljeflot, Christine Wisløff, Marie Lindvik Jørstad, Jim McVeigh, Anders Palmstrøm Jørgensen   +10 more
doaj   +1 more source

Proof of Concept and Preliminary Validation of an Analytical Model of an Energy Dissipator for Tension Loads with Self-Centering Capacity

Buildings, 2023
A novel energy dissipation device is proposed to protect structures against dynamic loads. A conceptual model of the device is presented, describing the fundamental components of its operation.
Nelson Maureira-Carsalade, Esteban Balboa-Constanzo, Marcelo Sanhueza-Cartes, Claudio Sanhueza, Eduardo Núñez, Ángel Roco-Videla   +5 more
doaj   +1 more source

Multidisciplinary Tumor Board Smart Virtual Assistant in Locally Advanced Cervical Cancer: A Proof of Concept [PDF]

, 2022
Gabriella Macchia, Gabriella Ferrandina, Stefano Patarnello, Rosa Autorino, Carlotta Masciocchi, Vincenzo Pisapia, Cristina Calvani, Chiara Iacomini, Alfredo Cesario, Luca Boldrini, Benedetta Gui, Vittoria Rufini, Maria Antonietta Gambacorta, Giovanni Scambia, Vincenzo Valentini   +14 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Forward and Inverse Robotics Kinematics JavaScript-HTML5 Simulator

Proceedings
The development of technology nowadays, and specifically in the field of robotics, is an increasingly developed field of research and development by the scientific community to optimize its productivity [...]
Spyridon Mitropoulos, Odysseas Tsakiridis, Ioannis Christakis   +2 more
doaj   +1 more source

A combined prosodic and linguistic treatment approach for language-communication skills in children with autism spectrum disorders: A proof-of-concept study

South African Journal of Childhood Education, 2016
This study aimed to determine whether the use of prosodically varied speech within a traditional language therapy framework had any effect on the listening skills, pragmatic skills and social interaction behaviour of three children with autism spectrum ...
Silva Kuschke, Bart Vinck, Salomé Geertsema   +2 more
doaj   +1 more source