Results 41 to 50 of about 310,350 (314)

Off-label use of clomiphene citrate to treat anabolic androgenic steroid induced hypogonadism upon cessation among men (CloTASH) – A pilot study protocol

MethodsX
Background: Non-prescribed anabolic androgenic steroid (AAS) use is associated with AAS-induced hypogonadism (ASIH), and metabolic, cardiovascular, and mental health risks.
Ingrid Amalia Havnes, Hans Christian Bordado Henriksen, Per Wiik Johansen, Astrid Bjørnebekk, Sudan Prasad Neupane, Jonny Hisdal, Ingebjørg Seljeflot, Christine Wisløff, Marie Lindvik Jørstad, Jim McVeigh, Anders Palmstrøm Jørgensen   +10 more
doaj   +1 more source

From proof-of-concept to exploitable

Cybersecurity, 2019
Exploitability assessment of vulnerabilities is important for both defenders and attackers. The ultimate way to assess the exploitability is crafting a working exploit. However, it usually takes tremendous hours and significant manual efforts. To address
Yan Wang, Wei Wu, Chao Zhang, Xinyu Xing, Xiaorui Gong, Wei Zou   +5 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Forward and Inverse Robotics Kinematics JavaScript-HTML5 Simulator

Proceedings
The development of technology nowadays, and specifically in the field of robotics, is an increasingly developed field of research and development by the scientific community to optimize its productivity [...]
Spyridon Mitropoulos, Odysseas Tsakiridis, Ioannis Christakis   +2 more
doaj   +1 more source

Challenges of commuter carpooling with adapting to Japanese customs and regulations: A pilot study

Transportation Research Interdisciplinary Perspectives, 2023
Commuter carpooling is a practical transportation demand management that promotes employees picking up and dropping off co-workers during their daily work commute.
Hidenobu Hashikami, Yu Li, Ryotaro Kobayashi, Maiko Shigeno   +3 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Artificial intelligence for the science of evidence synthesis: how good are AI-powered tools for automatic literature screening?

BMC Medical Research Methodology
Background Literature screening constitutes a critical component in evidence synthesis; however, it typically requires substantial time and human resources.
Minghao Ruan, Junhao Fan, Mingkai Liu, Zhengfeng Meng, Xiaohai Zhang, Chengjing Zhang   +5 more
doaj   +1 more source

Augmented reality-guided periacetabular osteotomy—proof of concept

Journal of Orthopaedic Surgery and Research, 2020
Background The Ganz’ periacetabular osteotomy (PAO) consists of four technically challenging osteotomies (OT), namely, supraacetabular (saOT), pubic (pOT), ischial (iOT), and retroacetabular OT (raOT).
Pascal Kiarostami, Cyrill Dennler, Simon Roner, Reto Sutter, Philipp Fürnstahl, Mazda Farshad, Stefan Rahm, Patrick O. Zingg   +7 more
doaj   +1 more source

Faire avec l’industrie

Revue d'anthropologie des connaissances, 2023
This article questions the social and institutional conditions by which, in the context of the expansion of entrepreneurial science, proofs of concept become a vector of scientific credibility in engineering sciences.
Benjamin Raimbault
doaj   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source