Results 61 to 70 of about 1,774,744 (290)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Off-label use of clomiphene citrate to treat anabolic androgenic steroid induced hypogonadism upon cessation among men (CloTASH) – A pilot study protocol

MethodsX
Background: Non-prescribed anabolic androgenic steroid (AAS) use is associated with AAS-induced hypogonadism (ASIH), and metabolic, cardiovascular, and mental health risks.
Ingrid Amalia Havnes, Hans Christian Bordado Henriksen, Per Wiik Johansen, Astrid Bjørnebekk, Sudan Prasad Neupane, Jonny Hisdal, Ingebjørg Seljeflot, Christine Wisløff, Marie Lindvik Jørstad, Jim McVeigh, Anders Palmstrøm Jørgensen   +10 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Forward and Inverse Robotics Kinematics JavaScript-HTML5 Simulator

Proceedings
The development of technology nowadays, and specifically in the field of robotics, is an increasingly developed field of research and development by the scientific community to optimize its productivity [...]
Spyridon Mitropoulos, Odysseas Tsakiridis, Ioannis Christakis   +2 more
doaj   +1 more source

The LifeV library: engineering mathematics beyond the proof of concept [PDF]

, 2017
LifeV is a library for the finite element (FE) solution of partial differential equations in one, two, and three dimensions. It is written in C++ and designed to run on diverse parallel architectures, including cloud and high performance computing ...
Bertagna, Luca, Deparis, Simone, Formaggia, Luca, Forti, Davide, Veneziani, Alessandro   +4 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Artificial intelligence for the science of evidence synthesis: how good are AI-powered tools for automatic literature screening?

BMC Medical Research Methodology
Background Literature screening constitutes a critical component in evidence synthesis; however, it typically requires substantial time and human resources.
Minghao Ruan, Junhao Fan, Mingkai Liu, Zhengfeng Meng, Xiaohai Zhang, Chengjing Zhang   +5 more
doaj   +1 more source

Development of a Continuous Pulsed Electric Field (PEF) Vortex-Flow Chamber for Improved Treatment Homogeneity Based on Hydrodynamic Optimization

Frontiers in Bioengineering and Biotechnology, 2020
Pulsed electric fields (PEF) treatment is an effective process for preservation of liquid products in food and biotechnology at reduced temperatures, by causing electroporation.
Felix Schottroff, Justus Knappert, Pauline Eppmann, Anna Krottenthaler, Tobias Horneber, Christopher McHardy, Cornelia Rauh, Henry Jaeger   +7 more
doaj   +1 more source

Design and proof of concept for silicon-based quantum dot quantum bits [PDF]

, 2002
Spins based in silicon provide one of the most promising architectures for quantum computing. Quantum dots are an inherently scalable technology. Here, we combine these two concepts into a workable design for a silicon-germanium quantum bit.
Eriksson, Mark A., Friesen, Mark, Joynt, Robert, Lagally, Max G., Rugheimer, Paul, Savage, Donald E., van der Weide, Daniel W.   +6 more
core   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source