Results 41 to 50 of about 1,774,744 (290)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Assessment of inverse publication bias in safety outcomes: an empirical analysis
BMC MedicineBackground The aims of this study were to assess the presence of inverse publication bias (IPB) in adverse events, evaluate the performance of visual examination, and explore the impact of considering effect direction in statistical tests for such ...
Xing Xing +4 more
doaj +1 more source
European Journal of Translational Myology, 2018 Myologists working in Padua (Italy) were able to continue a half-century tradition of studies of skeletal muscles, that started with a research on fever, specifically if and how skeletal muscle contribute to it by burning bacterial toxin.
Ugo Carraro
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Proof-of-Concept Experiments for Quantum Physics in Space
, 2003 Quantum physics experiments in space using entangled photons and satellites are within reach of current technology. We propose a series of fundamental quantum physics experiments that make advantageous use of the space infrastructure with specific ...
Aspelmeyer, Markus +6 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
BMC MedicineBackground Trial registration aims to address potential bias from selective or non-reporting of findings, and therefore has a vital role in promoting transparency and accountability of clinical research. In this study, we aim to investigate the influence
Chang Xu +8 more
doaj +1 more source
From proof-of-concept to exploitable
Cybersecurity, 2019 Exploitability assessment of vulnerabilities is important for both defenders and attackers. The ultimate way to assess the exploitability is crafting a working exploit. However, it usually takes tremendous hours and significant manual efforts. To address
Yan Wang +5 more
doaj +1 more source
Augmented reality-guided periacetabular osteotomy—proof of concept
Journal of Orthopaedic Surgery and Research, 2020 Background The Ganz’ periacetabular osteotomy (PAO) consists of four technically challenging osteotomies (OT), namely, supraacetabular (saOT), pubic (pOT), ischial (iOT), and retroacetabular OT (raOT).
Pascal Kiarostami +7 more
doaj +1 more source