Results 71 to 80 of about 1,488,747 (298)
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Including widespread geometry formats in semantic graphs using RDF literals [PDF]
, 2019 The exchange of building data involves both geometric and non-geometric data. A promising Linked Data approach is to embed data from existing geometry formats inside Resource Description Framework (RDF) literals.
Bonduel, Mathias +4 more
core +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Watching Eyes at Home: A Proof-of-Concept Study
Behavioral SciencesWaste separation in private households remains difficult to promote, particularly in urban contexts, where anonymity limits informal social monitoring.
Sabine Windmann
doaj +1 more source
Cellular vaccination of MLH1−/− mice – an immunotherapeutic proof of concept study
OncoImmunology, 2018 Mismatch-repair deficiency (MMR-D) is closely linked to hypermutation and accordingly, high immunogenicity. MMR-D-related tumors thus constitute ideal vaccination targets for both therapeutic and prophylactic approaches.
Claudia Maletzki +6 more
doaj +1 more source
Linking the anomaly initialization approach to the mapping paradigm: a proof-of-concept study [PDF]
, 2015 Seasonal-to-decadal predictions are initialized using observations of the present climatic state in full field initialization (FFI). Such model integrations undergo a drift toward the model attractor due to model deficiencies that incur a bias in the ...
Carrassi, Alberto +2 more
core +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
RNAi-mediated gene silencing in tick synganglia: A proof of concept study
BMC Biotechnology, 2008 Background Progress in generating comprehensive EST libraries and genome sequencing is setting the stage for reverse genetic approaches to gene function studies in the blacklegged tick (Ixodes scapularis).
Troiano Emily +3 more
doaj +1 more source
Implementing Single Source: The STARBRITE Proof-of-Concept Study [PDF]
Journal of the American Medical Informatics Association, 2007 Inefficiencies in clinical trial data collection cause delays, increase costs, and may reduce clinician participation in medical research. In this proof-of-concept study, we examine the feasibility of using point-of-care data capture for both the medical record and clinical research in the setting of a working clinical trial.
Rebecca, Kush +8 more
openaire +2 more sources
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source