Results 41 to 50 of about 167,450,079 (281)

Formal Barriers to Longest-Chain Proof-of-Stake Protocols

, 2019
The security of most existing cryptocurrencies is based on a concept called Proof-of-Work, in which users must solve a computationally hard cryptopuzzle to authorize transactions ("one unit of computation, one vote'').
Weinberg, Seth M, Psomas, Alexandros,, Arvind Narayanan, Brown-Cohen, Jonah,, S. Matthew Weinberg, Alexandros Psomas, Brown-Cohen, Jonah, Narayanan, Arvind, Jonah Brown-Cohen, Psomas, Alexandros, Weinberg, S. Matthew,, Narayanan, Arvind,   +11 more
core   +1 more source

Analysis of Blockchain consensus mechanisms : Proof-of-Work vs Proof-of-Stake [PDF]

, 2022
The objective of this thesis is to understand and evaluate the two popular consensus mechanisms of blockchain: Proof-of-Work (PoW) and Proof-of-Stake (PoS), especially in terms of their cost effectiveness.
Saif, Saba
core  

Formal Analysis of a Proof-of-Stake Blockchain [PDF]

2018 23rd International Conference on Engineering of Complex Computer Systems (ICECCS), 2018
Blockchain technology relies on consensus algorithms to resolve conflicts in Byzantine environments. New blockchain algorithms are rapidly designed and implemented without a properly conducted formal analysis and verification. In this paper, we conducted a study on Tendermint which is a proof of-stake consensus algorithm. We verified that the consensus
Wai Yan Maung Maung Thin, Naipeng Dong, Guangdong Bai, Jin Song Dong 0001   +3 more
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Coin concentration of Proof-of-Stake blockchains [PDF]

, 2023
This paper studies the concentration of block production in selected Proof-of-Stake (PoS) blockchains and finds evidence consistent with participants entering and leaving the consensus process, thereby changing the concentration level, but not with ...
Ruomei Yang, Yang, R, Yang, Ruomei, Irresberger, F, Felix Irresberger, Irresberger, Felix   +5 more
core   +1 more source

Impact of Saving Attacks on Blockchain Consensus

IEEE Access, 2021
Blockchain consensus, which enables nodes on a peer-to-peer network to agree on the same ledger history, is the core element of blockchain systems. In many blockchain systems, a node chosen as a block proposer, in accordance with the consensus protocol ...
Kai Otsuki, Ryuya Nakamura, Kazuyuki Shudo   +2 more
doaj   +1 more source

LaKSA: A Probabilistic Proof-of-Stake Protocol

Proceedings 2021 Network and Distributed System Security Symposium, 2021
We present Large-scale Known-committee Stake-based Agreement (LaKSA), a chain-based Proof-of-Stake protocol that is dedicated, but not limited, to cryptocurrencies. LaKSA minimizes interactions between nodes through lightweight committee voting, resulting in a simpler, more robust, and more scalable proposal than competing systems.
Daniël Reijsbergen, Pawel Szalachowski, Junming Ke, Zengpeng Li 0001, Jianying Zhou 0001   +4 more
openaire   +3 more sources

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source