Results 141 to 150 of about 150,676 (217)

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

open access: yesAdvanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot   +3 more
wiley   +1 more source

Proof Theory

open access: yesThe Reasoner
Francesca Poggiolesi
doaj  

Development and proof-of-concept of a complex intervention to support appropriate imaging for musculoskeletal pain: the Betti programme. [PDF]

open access: yesImplement Sci Commun
Lindner N   +7 more
europepmc   +1 more source

Programmable Functional Silicification of DNA Origami Nanostructures

open access: yesAdvanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist   +4 more
wiley   +1 more source

CPP–PEG‐Guided Surface Engineering of Mitochondria Enables Efficient Cellular Uptake and Respiratory Modulation

open access: yesAdvanced Materials Interfaces, EarlyView.
PEG‐guided mitochondrial surface engineering supports structural stabilization and controlled presentation of cell‐penetrating peptides. CPP–PEG‐modified mitochondria exhibit enhanced cellular uptake and uptake‐associated respiratory modulation, providing a proof‐of‐concept framework for modular organelle engineering and future bioenergetic modulation ...
Masahiro Shiraishi   +9 more
wiley   +1 more source

Material Before Morphology: Substrate‐Dependent Mechanical Tuning of Radular Teeth

open access: yesAdvanced Materials Interfaces, EarlyView.
Substrate‐dependent material tuning in Clausilia radular teeth. Closely related taxa retain a conserved gross tooth morphology, but differ in elemental composition and mechanical properties according to feeding substrate. Rock‐associated taxa show increased Ca–Si enrichment and higher stiffness and hardness, especially in the central radular region ...
Ida Lilienthal   +3 more
wiley   +1 more source

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