Results 31 to 40 of about 900,122 (234)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Detection of VLF Attenuation in the Earth‐Ionosphere Waveguide Caused by X‐Class Solar Flares Using aGlobal Lightning Location Network

Space Weather, 2020
Solar flares, energetic particles, and Earth‐impacting coronal mass ejections enhance ionization in the lower ionosphere, inhibiting radio wave propagation in the Earth‐ionosphere waveguide (EIWG).
T. S. Anderson, M. P. McCarthy, R. H. Holzworth   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Propagation and attenuation characteristics of shock waves in a gas–coal dust explosion in a diagonal pipeline network

Scientific Reports, 2022
In order to obtain the propagation and attenuation characteristics of a shock wave gas–coal dust explosion, a diagonal pipeline network was built to carry out a gas–coal dust explosion experiment.
Jinzhang Jia, Xiuyuan Tian
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Intrinsic noise within viscous solids and impact on material exploration

Frontiers in Physics
This paper introduces the concept of the intrinsic-noise-atom (i.e., intrinsic-noise-element) and its applications. We propose a method to extract intrinsic noise generated within viscous solids and discuss its impact on material exploration and analysis.
Lin Fa, Lin Fa, Shuangshuang Meng, Huiting Yang, Jinyue Li, Yaming Hu, Kaiqiang Zhang, Yulin Xu, Meishan Zhao   +8 more
doaj   +1 more source

Data-Driven Sparse Sampling for Reconstruction of Acoustic-Wave Characteristics Used in Aeroacoustic Beamforming

Applied Sciences, 2021
In this study, the propagation time and attenuation rate distributions of each sound source grid point (200 × 200) to a microphone of an arbitrary position across the shear layer, which are required for beamforming, were reconstructed by the reduced ...
Sayumi Kaneko, Yuta Ozawa, Kumi Nakai, Yuji Saito, Taku Nonomura, Keisuke Asai, Hiroki Ura   +6 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Discussion on the Discreteness of the Attenuation Parameters of the Peak Particle Velocity Induced by Blasting

Sensors
The research on the attenuation law of blasting vibration has become the foundation and precondition of the effective control of blasting vibration damage.
Zhaowei Yang, Yingguo Hu, Meishan Liu, Peng Li, Erlei Yao, Chenyang Ma   +5 more
doaj   +1 more source