Results 21 to 30 of about 1,467 (158)
Synthesis and Lipase-Catalyzed Resolution of 5-(Hydroxymethyl)-1,3-dioxolan-4-ones: Masked Glycerol Analogs as Potential Building Blocks for Pharmaceuticals [PDF]
, 1996 (Hydroxymethyl)-1,3-dioxolan-4-ones from mandelic and lactic acids and 1,5,5-trimethyl-3-phenyloxazolidin-2-one from mandelamide were α-alkylated using benzyl chloromethyl ether.
Kellogg, Richard M., +3 more
core +1 more source
Enantiomeric Propanolamines as selective N-Methyl-d-aspartate 2B Receptor Antagonists
, 2016 Enantiomeric propanolamines have been identified as a new class of NR2B-selective NMDA receptor antagonists. The most effective agents are biaryl structures, synthesized in six steps with overall yields ranging from 11−64%.
James O. McNamara (2417191) +17 more
core +1 more source
Synthesis and antitumor activity of enantiomerically pure [1,2-diamino-1-(4-fluorophenyl)propane]dichloroplatinum(II) complexes. [PDF]
, 2002 Enantiomerically pure 1, 2-diamino-1-(4-fluorophenyl)propanes were synthesized by stereospecific and stereoselective procedures by use of the (1R, 2S)- and (1S, 2R)-2-amino-1-(4-fluorophenyl)propanols (12a) as intermediates.
Michael Gelbcke +7 more
core +1 more source
Journal of Drug Delivery, Volume 2017, Issue 1, 2017., 2017 The crystallization of mefenamic acid in transdermal patch is a major problem that makes the patch unstable and decreases the drug release. The additive was used to inhibit crystallization of a mefenamic acid. Among the different types of additives, polyvinylpyrrolidone (PVP) K30 and PVP K90 were studied and found to be highly effective in inhibiting ...
Jirapornchai Suksaeree +3 more
wiley +1 more source
, 2016 A set of 280 5-HT1A receptor ligands were selected from available literature data according to predefined criteria and subjected to three-dimensional quantitative structure−affinity relationship analysis using comparative molecular field analysis.
Pierre-Alain Carrupt (522894) +3 more
core +1 more source
Journal of Spectroscopy, Volume 2016, Issue 1, 2016., 2016 We report results of a systematic Raman, SERS, and DFT study on four beta blocking molecules: Atenolol, Metoprolol, Propranolol, and, for the first time reported in the literature, Bisoprolol. The choice of these molecules was motivated by the structural similarities between Atenolol, Bisoprolol, and Metoprolol on one hand and by their differences ...
A. Farcaș +6 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot +2 more
wiley +1 more source
Experience (Mostly Negative) with the Use of Sympathomimetic Agents for Weight Loss
Journal of Obesity, Volume 2011, Issue 1, 2011., 2011 Sympathomimetic agents have a poor history of long‐term success in the treatment of obesity. From earlier experiences with amphetamine and its analogs, to more recent drugs with direct effects on adrenergic receptors or indirect effects from release of catecholamines or inhibition of reuptake, cardiovascular toxicity (strokes and cardiac arrhythmias ...
Mario A. Inchiosa Jr., A. Halpern
wiley +1 more source
Advanced Functional Materials, Volume 36, Issue 28, 7 April 2026.A novel approach for the design of functional semiconductors is presented, which utilizes the excellent optoelectronic properties of layered hybrid perovskites and the possibility to introduce a molecular photoswitch as the organic spacer. This concept is successfully demonstrated on a coumarin‐based system with the possibility to change the bandgap ...
Oliver Treske +4 more
wiley +1 more source
Real‐Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe
Advanced Science, Volume 12, Issue 42, November 13, 2025.The first reversible binding probe (rNTRp) is presented that selectively detects the nitroreductase enzyme's active, reduced form (red‐NTR) with a fluorescence turn‐on response. Contrary to the conventional reaction‐based probes known to date, which provide only static information on the accumulated enzyme activity at a given time, rNTRp allows ...
Sourav Sarkar +8 more
wiley +1 more source