Results 61 to 70 of about 16,925,620 (257)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Geofluids, 2021 Shale oil and gas reservoirs are developed by MFHWs. After large-scale hydraulic fracturing, it is hard to forecast the production rate using the theoretical method.
Ling Chen +5 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Forts. bildet: Francke, Christian Daniel: Auff einen Actum Oratorium von den Glocken, Welchen den 22. Sept. 1736. Die Schul-Jugend zu Lennep. - 1736Autopsie nach Ex.
Francke, Daniel Christian
core +1 more source
Development of a Numerical Model for an Expanding Tube with Linear Explosive Using AUTODYN
Shock and Vibration, 2014 Pyrotechnic devices have been employed in satellite launch vehicle missions, generally for the separation of structural subsystems such as stage and satellite separation.
Mijin Choi +2 more
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
A Complex Design of the Integrated Forward-Reverse Logistics Network under Uncertainty
International Journal of Industrial Engineering and Production Research, 2012 Design of a logistics network in proper way provides a proper platform for efficient and effective supply chain management. This paper studies a multi-period, multi echelon and multi-product integrated forward-reverse logistics network under uncertainty.
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doaj