Results 171 to 180 of about 16,754,236 (393)

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Software y Firmware. Algunas cuestiones jurídicas

open access: yesRevista Iberoamericana de la Propiedad Intelectual, 2013
El software constituye uno de los elementos de mayor desarrollo e importancia en las economías contemporáneas. Sin embargo, pese a la enorme cantidad de relaciones jurídicas a él vinculadas, son escasos en nuestro país los fallos que permiten delimitar ...
Guillermo Cabanellas de las Cuevas
doaj  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

A Simple Proof of the Restricted Isometry Property for Random Matrices

open access: yes, 2008
Richard Baraniuk   +3 more
semanticscholar   +1 more source

Invenciones farmacéuticas en la República Argentina

open access: yesRevista Iberoamericana de la Propiedad Intelectual, 2013
Aunque la vieja Ley de Patentes N° 111, a través de su art. 4, estableció que las composiciones farmacéuticas no serían susceptibles de patentamiento, no es menos cierto que dicha ley fue sancionada en 1864, y que en esa época el concepto de ...
Miguel Ángel Aulmann
doaj  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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