Results 41 to 50 of about 6,676,736 (296)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa   +3 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

In Defense of Property [PDF]

open access: yes, 2008
This Article responds to an emerging view, in scholarship and popular society, that it is normatively undesirable to employ property law as a means of protecting indigenous cultural heritage. Recent critiques suggest that propertizing culture impedes the
Carpenter, Kristen A.   +2 more
core   +3 more sources

Methods and Models of a Program Complex of Protection and Support of Subjects and Objects of the Industrial Property in the Internet/Intranet

open access: yesБезопасность информационных технологий, 2013
The basic methods and the models, the developed software of protection and active support in a network of subjects and objects of the industrial property (inventions and useful models) are considered.
Sergey Pavlovich Botuz   +3 more
doaj  

Property as Intangible Property

open access: yes, 2020
Abstract Historically, property theory has focused on real property as the premier example of property, reflecting the longstanding importance of land as a source of wealth and political power. This essay argues that it is time for property theorists to pay more attention to intangible property. It makes three main points.
openaire   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Pitfalls of patenting and state authorization of medicines

open access: yesРегуляторные исследования и экспертиза лекарственных средств, 2018
During the lifecycle of a medicine - from its development to consumption - the developer has to go through several stages, such as obtaining the exclusive right for a medicine, obtaining permission to produce the medicine, obtaining permission to ...
V. I. Semenov   +2 more
doaj  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Technology mapping: Leukemia Treatment

open access: yesRevista CENIC Ciencias Químicas, 2015
The increase in the incidence of various cancers has been one of the biggest challenges in the global public health for decades. Leukemia is a type of cancer that only in 2008 has affected 351,000 people of the world population.
Luciene Ferreira Gaspar Amaral   +2 more
doaj  

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