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Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher+6 more
wiley +1 more source
On the stickiness property [PDF]
In [2] the notion of stickiness for stochastic processes was introduced. It was also shown that stickiness implies absense of arbitrage in a market with proportional transaction costs. In this paper, we investigate the notion of stickiness further. In particular, we give examples of processes that are not semimartingales but are sticky.
Erhan Bayraktar, Hasanjan Sayit
openaire +3 more sources
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
Pitfalls of patenting and state authorization of medicines
During the lifecycle of a medicine - from its development to consumption - the developer has to go through several stages, such as obtaining the exclusive right for a medicine, obtaining permission to produce the medicine, obtaining permission to ...
V. I. Semenov+2 more
doaj
Privacy, Private Property and Collective Property [PDF]
In A Theory of Justice John Rawls argued that people in a just society would have rights to some forms of personal property, whatever the best way to organise the economy. Without being explicit about it, he also seems to have believed that protection for at least some forms of privacy are included in the Basic Liberties, to which all are entitled ...
openaire +5 more sources
Live Stream of the 9th Circuit Skidmore V. Led Zeppelin Oral Argument [PDF]
https://larc.cardozo.yu.edu/event-invitations-2019/1053/thumbnail ...
Cardozo Intellectual Property & Information Law Program+1 more
core +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga+6 more
wiley +1 more source
Technology mapping: Leukemia Treatment
The increase in the incidence of various cancers has been one of the biggest challenges in the global public health for decades. Leukemia is a type of cancer that only in 2008 has affected 351,000 people of the world population.
Luciene Ferreira Gaspar Amaral+2 more
doaj
Property, Intellectual Property, and Free Riding [PDF]
Courts and scholars have increasingly assumed that intellectual property isa form of property, and have applied the economic insights of HaroldDemsetz and other property theorists to condemn the use of intellectualproperty by others as "free riding." In this article, I argue that thisrepresents a fundamental misapplication of the economic theory of ...
openaire +4 more sources
Are mental properties supervenient on brain properties? [PDF]
9 pages, 2 ...
Carey E. Priebe+2 more
openaire +3 more sources