Results 71 to 80 of about 8,906,865 (345)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Technological Monitoring Applied to Survey-Based on Brazilian Patent Applications about PEMFC
Journal of Technology Management & Innovation, 2011 The present study aims to show the importance of patents as an instrument of technological innovation and to assess the relevance of technology of PEMFC in Brazil by means of the technological monitoring methodology from 1996 to 2005.
Deysimar de Souza Carvalho +3 more
doaj +1 more source
Is there a “case for property” all the time? [PDF]
, 2002 The “case for property” in the mixed-asset portfolio is a topic of continuing interest to practitioners and academics. Such an analysis typically is performed over a fixed period of time and the optimum allocation to property inferred from the weight ...
Lee, Stephen
core
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Безопасность информационных технологий, 2015 Methods and models of graph-analytic synthesis of network reports of protection and support of essentially nonlinear dynamic search processes and systems are considered.
Sergey Pavlovich Botuz +1 more
doaj
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source
Mapping unobserved coopetitions between shopping malls using mobile geolocation data
Regional Studies, Regional ScienceThis study challenges the conventional retail catchment analysis, which typically asserts that proximity is the primary driver of shopping mall patronage.
Yihan Guan +2 more
doaj +1 more source
Journal of Technology Management & Innovation, 2013 The present article aims to assess the innovative activity in the Brazilian most representative sector in biotechnology field. The search was conducted through patent applications of residents at the National Institute of Industrial Property (INPI ...
Liliana Machado Mendes +2 more
doaj +1 more source
Australian intellectual property report 2013 [PDF]
This report provides a collation of data and information about the IP system in Australia, where Australia sits in the global IP system, and how it measures up against other countries.
Intellectual Property (IP) Australia
core +2 more sources