Results 131 to 140 of about 380,665 (285)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A transformer model for cause-specific hazard prediction

BMC Bioinformatics
Backgroud Modelling discrete-time cause-specific hazards in the presence of competing events and non-proportional hazards is a challenging task in many domains.
Matthieu Oliver, Nicolas Allou, Marjolaine Devineau, Jèrôme Allyn, Cyril Ferdynus   +4 more
doaj   +1 more source

An online framework for survival analysis: reframing Cox proportional hazards model for large data sets and neural networks. [PDF]

Biostatistics, 2023
Tarkhan A, Simon N.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Sure Joint Screening for High Dimensional Cox's Proportional Hazards Model Under the Case-Cohort Design. [PDF]

J Comput Biol, 2023
Liu Y, Li G.
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Properties and inference for proportional Hazard models

Revista Colombiana de Estadística, 2013
We consider an arbitrary continuous cumulative distribution function F(x) with a probability density function f(x) = dF(x)/dx and hazard function h f(x)=f(x)/[1-F(x)]. We propose a new family of distributions, the so-called proportional hazard distribution-function, whose hazard function is proportional to h f(x).
MARTÍNEZ-FLÓREZ, GUILLERMO, MORENO-ARENAS, GERMÁN, VERGARA-CARDOZO, SANDRA   +2 more
openaire   +4 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

ESTIMATION AND INFERENCE FOR EXPOSURE EFFECTS WITH LATENCY IN THE COX PROPORTIONAL HAZARDS MODEL IN THE PRESENCE OF EXPOSURE MEASUREMENT ERROR. [PDF]

Ann Appl Stat, 2023
Peskoe SB, Zhang N, Spiegelman D, Wang M.   +3 more
europepmc   +1 more source