Results 141 to 150 of about 228,669 (304)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Proportional Hazards Model for Predictors of Type 2 Diabetes Mellitus among the Elderly

JLUMHS
OBJECTIVE: To find the prevalence and prognostic characteristics of type 2 diabetes mellitus (T2DM) in older adults. METHODOLOGY: This study's quantitative observational approach utilized the Cox proportional hazards model. This study was conducted from
Marjes N Tumurang, Indra Elisabet Lalangpuling   +1 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Factors Affecting the Survival of Patients with Gastric Cancer Undergone Surgery at Iran Cancer Institute: Univariate and Multivariate Analyses.

Iranian Journal of Public Health, 2014
Gastric cancer is the most prevalent cancer among men and the third most prevalent cancer among women in Iran. Its most important reason for death is its belated diagnosis at the advanced stages of the disease.
Ali Zare, Mahmood Mahmoodi, Kazem Mohammad, Hojjat Zeraati, Mostafa Hosseini, Kourosh Holakouie Naieni   +5 more
doaj  

Testing goodness-of-fit for the proportional hazards model based on nested case-control data [PDF]

, 2014
[[sponsorship]]統計科學研究所[[note]]出版中(submitted);沒有審查制度 ...
Lu, W.;Liu, M.;Chen, Y. -H.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A Goodness-of-Fit Test for Log-Linearity in Cox Proportional Hazards Model Under Monotonic Covariate Effects

Mathematics
The Cox proportional hazards (PH) model is widely used because it models the covariates to the hazard through a log-linear effect. However, exploring flexible effects becomes desirable within the Cox PH framework when only a monotonic relationship ...
Huan Chen, Chuan-Fa Tang
doaj   +1 more source

Healthcare center clustering for Cox's proportional hazards model by fusion penalty. [PDF]

Stat Med, 2023
Liu L, He K, Wang D, Ma S, Qu A, Lin L, Miller JP, Liu L.   +7 more
europepmc   +1 more source

A note on proportional hazards and proportional odds models [PDF]

The proportional hazards model has been used as a major model for analyzing survival data. When there are heavy ties, the proportional odds model is often recommended as an alternative. In this paper, we explore theoretical properties of these two models.
Manatunga, Amita K., Chen, Shande
core