Results 161 to 170 of about 228,669 (304)

ESTIMATION AND INFERENCE FOR EXPOSURE EFFECTS WITH LATENCY IN THE COX PROPORTIONAL HAZARDS MODEL IN THE PRESENCE OF EXPOSURE MEASUREMENT ERROR. [PDF]

Ann Appl Stat, 2023
Peskoe SB, Zhang N, Spiegelman D, Wang M.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Penalized weighted proportional hazards model for robust variable selection and outlier detection. [PDF]

Stat Med, 2022
Luo B, Gao X, Halabi S.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Prognostic analysis of breast cancer in Xinjiang based on Cox proportional hazards model and two-step cluster method. [PDF]

Front Oncol, 2022
Wu M, Zhao T, Zhang Q, Zhang T, Wang L, Sun G.   +5 more
europepmc   +1 more source

A note on the proportional hazards model with discontinuous data [PDF]

Cox's proportional hazards (PH) model is applicable to continuous random (response) variables as well as to discontinuous ones. We make two remarks on the PH models for discontinuous random (response) variables.
Yu, Qiqing
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Modeling Survival Analysis in Gastric Cancer Patients Using the Proportional Hazards Model of Cox

مجله اپیدمیولوژی ایران, 2007
Background & Objectives: Cancer has been traditionally regarded as a fatal disease; it is a major public health problem in many countries throughout the world.
B Moghimi Dehkordi, A Rajaeefard, HR Tabatabaee, B Zeighami, A Safaee, Z Tabeie   +5 more
doaj  

Maximum Likelihood Estimation for Cox Proportional Hazards Model with a Change Hyperplane. [PDF]

Stat Sin, 2022
Deng Y, Cai J, Zeng D.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source